methyl 3-(3-(4-phenyl-1H-1,2,3-triazol-1-yl)bicyclo[1.1.1]pentan-1-yl)propanoate

Base Information

• Chemical Name: methyl 3-(3-(4-phenyl-1H-1,2,3-triazol-1-yl)bicyclo[1.1.1]pentan-1-yl)propanoate
• CAS No.: 1581682-02-1
• Molecular Formula: C₁₇H₁₉N₃O₂
• Molecular Weight: 297.357
• Mol file: 1581682-02-1.mol

Synonyms:methyl 3-(3-(4-phenyl-1H-1,2,3-triazol-1-yl)bicyclo[1.1.1]pentan-1-yl)propanoate

Chemical Property of methyl 3-(3-(4-phenyl-1H-1,2,3-triazol-1-yl)bicyclo[1.1.1]pentan-1-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(3-(4-phenyl-1H-1,2,3-triazol-1-yl)bicyclo[1.1.1]pentan-1-yl)propanoate

There total 3 articles about methyl 3-(3-(4-phenyl-1H-1,2,3-triazol-1-yl)bicyclo[1.1.1]pentan-1-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-(3-iodobicyclo[1.1.1]pentan-1-yl)-4-phenyl-1H-1,2,3-triazole (1581682-00-9) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 1-(bicyclo[1.1.1]pentan-1-yl)-4-phenyl-1H-1,2,3-triazole (1581682-01-0) + methyl 3-(3-(4-phenyl-1H-1,2,3-triazol-1-yl)bicyclo[1.1.1]pentan-1-yl)propanoate (1581682-02-1)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; at 80 ℃; for 3.5h; Inert atmosphere;

DOI:10.1021/ol500635p

Reference yield:

phenylacetylene (536-74-3) → 1-(bicyclo[1.1.1]pentan-1-yl)-4-phenyl-1H-1,2,3-triazole (1581682-01-0) + methyl 3-(3-(4-phenyl-1H-1,2,3-triazol-1-yl)bicyclo[1.1.1]pentan-1-yl)propanoate (1581682-02-1)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; triethylamine / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

2: tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) / benzene / 3.5 h / 80 °C / Inert atmosphere

With copper(l) iodide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine; In tetrahydrofuran; benzene;

DOI:10.1021/ol500635p

Reference yield:

1-azido-3-iodobicyclo<1.1.1>pentane (136863-38-2) → 1-(bicyclo[1.1.1]pentan-1-yl)-4-phenyl-1H-1,2,3-triazole (1581682-01-0) + methyl 3-(3-(4-phenyl-1H-1,2,3-triazol-1-yl)bicyclo[1.1.1]pentan-1-yl)propanoate (1581682-02-1)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; triethylamine / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

2: tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) / benzene / 3.5 h / 80 °C / Inert atmosphere

With copper(l) iodide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine; In tetrahydrofuran; benzene;

DOI:10.1021/ol500635p

upstream raw materials:

phenylacetylene

1-(3-iodobicyclo[1.1.1]pentan-1-yl)-4-phenyl-1H-1,2,3-triazole

acrylic acid methyl ester

1-azido-3-iodobicyclo<1.1.1>pentane