(2R,3S)-3-((1-fluorocyclobutyl)methyl)-N-((3S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide

Base Information

Chemical Name:(2R,3S)-3-((1-fluorocyclobutyl)methyl)-N-((3S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide
CAS No.:1584139-23-0
Molecular Formula:C₂₈H₃₀F₄N₄O₃
Molecular Weight:546.565
Hs Code.:

Synonyms:(2R,3S)-3-((1-fluorocyclobutyl)methyl)-N-((3S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide

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Chemical Property of (2R,3S)-3-((1-fluorocyclobutyl)methyl)-N-((3S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide

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Technology Process of (2R,3S)-3-((1-fluorocyclobutyl)methyl)-N-((3S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide

There total 5 articles about (2R,3S)-3-((1-fluorocyclobutyl)methyl)-N-((3S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1584139-82-1
(S)-3-amino-9-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1584139-34-3
(R)-2-((S)-1-amino-3-(1-fluorocyclobutyl)-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid

: 1584139-23-0
(2R,3S)-3-((1-fluorocyclobutyl)methyl)-N-((3S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; water; at 20 ℃; Cooling with ice;

Reference yield:

: 5054-32-0
(2-amino-3-methylphenyl)(phenyl)methanone

: 1584139-23-0
(2R,3S)-3-((1-fluorocyclobutyl)methyl)-N-((3S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 0 °C

1.2: 2.5 h / 20 °C

2.1: hydrogen bromide / acetic acid / 2 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; water / 20 °C / Cooling with ice

With oxalyl dichloride; hydrogen bromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: tert-butyl 5,5,5-trifluoro-2-((S)-3-(1-fluorocyclobutyl)-1-((R)-4-isopropyl-2-oxooxazolidin-3-yl)-1-oxopropan-2-yl)pentanoate

: 1584139-23-0
(2R,3S)-3-((1-fluorocyclobutyl)methyl)-N-((3S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 0 - 20 °C

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; water / 20 °C / Cooling with ice

With dihydrogen peroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;