5054-32-0

Usage

General Description

2-Amino-3-methylbenzophenone, also known as 2-aminobenzophenone-3 or Oxybenzone-4, is a chemical compound with the molecular formula C14H13NO. It is a yellow crystalline solid that is commonly used as a sunscreen ingredient to absorb and reflect UV radiation. 2-Amino-3-methylbenzophenone is part of the benzophenone family and is added to sunscreens, lip balms, and other personal care products to protect the skin from sun damage. However, concerns have been raised about its potential to cause skin allergies and hormone disruption. It has been banned in some countries or restricted in its use due to these health and environmental concerns.

Upstream product

• 60288-17-7 2,8-dimethyl-4H-3,1-benzoxazin-4-one 
• 100-47-0 benzonitrile 
• 95-53-4 o-toluidine 
• 584-70-3 N-benzoyl-2-methylaniline 
• 60288-18-8 N-(2-benzoyl-6-methylphenyl)acetamide 
• 4389-45-1 3-methylantranilic acid 
• 108-86-1 bromobenzene 
• 886574-89-6 2-amino-N-methoxy-N,3-dimethylbenzamide 

Downstream Products

• 114623-44-8 7-methyl-3-phenyl-2,1-benzisoxazole 
• 80726-58-5 (2-chloro-3-methylphenyl)phenylmethanone 
• 1584139-99-0 benzyl (9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate 
• 1584139-93-4 (S)-benzyl (9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamate 
• 1584139-82-1 (S)-3-amino-9-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one 
• 4937-64-8 9-methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one 
• 52164-35-9 (2-iodo-3-methylphenyl)(phenyl)methanone 
• 1584139-23-0 (2R,3S)-3-((1-fluorocyclobutyl)methyl)-N-((3S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide 
• 80726-61-0 3-benzoyl-2-chlorobenzeneacetic acid 
• 80726-60-9 3-benzoyl-2-chlorobenzeneacetonitrile 
• 80726-59-6 (3-Bromomethyl-2-chloro-phenyl)-phenyl-methanone 
• 60287-75-4 2-Benzyl-6-methylanilin 

Relevant academic research and scientific papers

Atropisomeric Properties of 9-Methyl-1,4-benzodiazepin-2-ones

The atropisomeric and conformational properties of 1,4-benzodiazepin-2-ones were investigated by freezing the conformation with a methyl group at the C9 of 1,4-benzodiazepine. It was revealed that 1,4-benzodiazepin-2-ones exist only as a pair of enantiome

Visible Light Induced Cyclization to Spirobi[indene] Skeletons from Functionalized Alkylidienecyclopropanes

In this paper, we revealed a metal-free and visible light photoinduced method for the rapid construction of spirobi[indene] skeletons, providing a simple and efficient way for easy access to spirobi[indene] scaffolds under mild conditions along with a broad substrate scope and good functional group tolerance.

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration

An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction of an enhanced library of unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage of a stronger C?O bond and formation of a weaker C?C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.

Synthesis of Diiodinated All-Carbon 3,3′-Diphenyl-1,1′-spirobiindene Derivatives via Cascade Enyne Cyclization and Electrophilic Aromatic Substitution

A synthetic method for the construction of diiodinated all-carbon spirobiindene derivatives has been developed from the reaction of propargyl alcohol-tethered alkylidenecyclopropanes with iodine. The reaction proceeded through an iodination-initiated cascade intramolecular enyne cyclization and electrophilic aromatic substitution reaction process in 1,2-dichloroethane upon heating, giving desired spirocyclic products in moderate to excellent yields. Further transformation of the obtained products has also been presented.

Palladium-Catalyzed Cascade Reductive and Carbonylative Cyclization of Ortho-Iodo-Tethered Methylenecyclopropanes (MCPs) Using N-Formylsaccharin as CO Source

A palladium-catalyzed reductive and carbonylative cyclization of ortho-iodo-tethered methylenecyclopropanes (MCPs) using N-formylsaccharin as CO source has been developed, affording the desired indanone derivatives in moderate to good yields with high regio- and stereoselectivity and good functional group compatibility.

Lewis or Br?nsted acid-catalysed reaction of propargylic alcohol-tethered alkylidenecyclopropanes with indoles and pyrroles for the preparation of polycyclic compounds tethered with indole or pyrrole motif

We developed a facile synthetic method to access cyclopenta[b]naphthalene derivatives via the Lewis or Br?nsted acid catalysed cascade nucleophilic addition, electronic cyclization, ring-opening rearrangement of propargylic alcohol-tethered alkylidenecyclopropanes with indole and pyrrole derivatives. The reaction exhibited a broad substrate scope and good functional group tolerance under metal-free conditions, affording the desired products in moderate to good yields.

SURFACE PHOTOCHEMISTRY: THE AMIDE PHOTO-FRIES REARRANGEMENT

The Photo-Fries rearrangement of eight anilides on the surface of dry silica gel has been examined.The rearrangement occurs quite cleanly, giving somewhat more of the para isomer than that obtained in methanolic solution.A test for intermolecularity on the silica gel surface showed that, as in solution, the radical pair intermediates do not separate.This contrasts with the behaviour of a previously reported dibenzyl ketone derivate.