(2-chloro-4,6-dimethyl-phenyl)-{5-[(cyclopropylmethyl-propyl-amino)-methyl]-4-trifluoromethylthiazol-2-yl}-amine

Base Information

Chemical Name:(2-chloro-4,6-dimethyl-phenyl)-{5-[(cyclopropylmethyl-propyl-amino)-methyl]-4-trifluoromethylthiazol-2-yl}-amine
CAS No.:405879-20-1
Molecular Formula:C₂₀H₂₅ClF₃N₃S
Molecular Weight:431.953
Hs Code.:

Synonyms:(2-chloro-4,6-dimethyl-phenyl)-{5-[(cyclopropylmethyl-propyl-amino)-methyl]-4-trifluoromethylthiazol-2-yl}-amine

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Chemical Property of (2-chloro-4,6-dimethyl-phenyl)-{5-[(cyclopropylmethyl-propyl-amino)-methyl]-4-trifluoromethylthiazol-2-yl}-amine

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Technology Process of (2-chloro-4,6-dimethyl-phenyl)-{5-[(cyclopropylmethyl-propyl-amino)-methyl]-4-trifluoromethylthiazol-2-yl}-amine

There total 2 articles about (2-chloro-4,6-dimethyl-phenyl)-{5-[(cyclopropylmethyl-propyl-amino)-methyl]-4-trifluoromethylthiazol-2-yl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 724426-20-4
2-(2-chloro-4,6-dimethyl-phenylamino)-4-trifluoromethyl-thiazole-5-carboxylic acid ethyl ester

: 405879-20-1
(2-chloro-4,6-dimethyl-phenyl)-{5-[(cyclopropylmethyl-propyl-amino)-methyl]-4-trifluoromethylthiazol-2-yl}-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Me₃Al / toluene / 14 h / Heating

2.1: BH₃*THF / 16 h / Heating

2.2: MeOH / 1 h / Heating

With borane-THF; trimethylaluminum; In toluene;
DOI:10.1016/j.bmcl.2003.08.055

Reference yield:

: 643747-97-1
2-(2-chloro-4,6-dimethyl-phenylamino)-4-trifluoromethyl-thiazole-5-carboxylic acid cyclopropylmethyl-propyl-amide

: 405879-20-1
(2-chloro-4,6-dimethyl-phenyl)-{5-[(cyclopropylmethyl-propyl-amino)-methyl]-4-trifluoromethylthiazol-2-yl}-amine

Guidance literature:: 2-(2-chloro-4,6-dimethyl-phenylamino)-4-trifluoromethyl-thiazole-5-carboxylic acid cyclopropylmethyl-propyl-amide; With borane-THF; for 16h; Heating;

With methanol; for 1h; Heating;
DOI:10.1016/j.bmcl.2003.08.055