2-({2-[2-((2-benzyloxycarbonylaminoacetyl){[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}amino)-3-phenylpropionylamino]acetyl}trimethylsilanylmethylamino)-3-phenylpropionic acid methyl ester

Base Information

Chemical Name:2-({2-[2-((2-benzyloxycarbonylaminoacetyl){[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}amino)-3-phenylpropionylamino]acetyl}trimethylsilanylmethylamino)-3-phenylpropionic acid methyl ester
CAS No.:916049-43-9
Molecular Formula:C₄₆H₆₀N₄O₉Si₂
Molecular Weight:869.175
Hs Code.:

2-({2-[2-((2-benzyloxycarbonylaminoacetyl){[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}amino)-3-phenylpropionylamino]acetyl}trimethylsilanylmethylamino)-3-phenylpropionic acid methyl ester

Synonyms:2-({2-[2-((2-benzyloxycarbonylaminoacetyl){[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}amino)-3-phenylpropionylamino]acetyl}trimethylsilanylmethylamino)-3-phenylpropionic acid methyl ester

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Chemical Property of 2-({2-[2-((2-benzyloxycarbonylaminoacetyl){[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}amino)-3-phenylpropionylamino]acetyl}trimethylsilanylmethylamino)-3-phenylpropionic acid methyl ester

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Technology Process of 2-({2-[2-((2-benzyloxycarbonylaminoacetyl){[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}amino)-3-phenylpropionylamino]acetyl}trimethylsilanylmethylamino)-3-phenylpropionic acid methyl ester

There total 10 articles about 2-({2-[2-((2-benzyloxycarbonylaminoacetyl){[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}amino)-3-phenylpropionylamino]acetyl}trimethylsilanylmethylamino)-3-phenylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 916049-47-3
2-(aminoacetyl-trimethylsilanylmethyl-amino)-3-phenyl-propionic acid methyl ester

: 609347-87-7
2-(benzyloxycarbonylaminoacetyl-{[(2,4-dimethoxy-phenyl)-dimethyl-silanyl]-methyl}-amino)-3-phenyl-propionic acid

: 916049-43-9
2-({2-[2-((2-benzyloxycarbonylaminoacetyl){[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}amino)-3-phenylpropionylamino]acetyl}trimethylsilanylmethylamino)-3-phenylpropionic acid methyl ester

Guidance literature:: With 2,4,6-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/ja064737l

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 916049-43-9
2-({2-[2-((2-benzyloxycarbonylaminoacetyl){[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}amino)-3-phenylpropionylamino]acetyl}trimethylsilanylmethylamino)-3-phenylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / potassium iodide; potassium carbonate / dimethylformamide / 12 h / 90 °C

2: 3.2 g / CH₂Cl₂ / 12 h / 20 °C

3: aq. HCl / ethyl acetate / 0.5 h / 20 °C

4: 237 mg / HBTU; HOAT; 2,4,6-collidine / dimethylformamide / 16 h / 20 °C

With 2,4,6-trimethyl-pyridine; hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; potassium iodide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja064737l

Reference yield:

: 2-(benzyloxycarbonylaminoacetyl-{[(2,4-dimethoxy-phenyl)-dimethyl-silanyl]-methyl}-amino)-3-phenyl-propionic acid methyl ester

: 916049-43-9
2-({2-[2-((2-benzyloxycarbonylaminoacetyl){[(2,4-dimethoxyphenyl)dimethylsilanyl]methyl}amino)-3-phenylpropionylamino]acetyl}trimethylsilanylmethylamino)-3-phenylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: LiOH / methanol; H₂O / 3 h / 0 °C

2: 237 mg / HBTU; HOAT; 2,4,6-collidine / dimethylformamide / 16 h / 20 °C

With 2,4,6-trimethyl-pyridine; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ja064737l