4-(4-fluorophenyl)-2-(4-methoxybenzyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl)pyrazole-1-oxide

Base Information

Chemical Name:4-(4-fluorophenyl)-2-(4-methoxybenzyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl)pyrazole-1-oxide
CAS No.:438193-74-9
Molecular Formula:C₃₁H₂₇FN₂O₃
Molecular Weight:494.565
Hs Code.:

Synonyms:4-(4-fluorophenyl)-2-(4-methoxybenzyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl)pyrazole-1-oxide

Suppliers and Price of 4-(4-fluorophenyl)-2-(4-methoxybenzyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl)pyrazole-1-oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(4-fluorophenyl)-2-(4-methoxybenzyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl)pyrazole-1-oxide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(4-fluorophenyl)-2-(4-methoxybenzyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl)pyrazole-1-oxide

There total 7 articles about 4-(4-fluorophenyl)-2-(4-methoxybenzyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl)pyrazole-1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1765-93-1
4-fluoroboronic acid

: 438193-72-7
4-bromo-2-(4-methoxybenzyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl)pyrazole-1-oxide

: 438193-74-9
4-(4-fluorophenyl)-2-(4-methoxybenzyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl)pyrazole-1-oxide

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; for 5h;
DOI:10.1021/jo015997i

Reference yield: 64.0%

: 352-34-1
4-fluoro-1-iodobenzene

: 438193-72-7
4-bromo-2-(4-methoxybenzyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl)pyrazole-1-oxide

: 438193-74-9
4-(4-fluorophenyl)-2-(4-methoxybenzyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl)pyrazole-1-oxide

Guidance literature:: 4-bromo-2-(4-methoxybenzyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl)pyrazole-1-oxide; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 0.333333h;

With zinc(II) chloride; In tetrahydrofuran; at -78 - 20 ℃; for 0.5h;

4-fluoro-1-iodobenzene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃; for 10h; Further stages.;
DOI:10.1021/jo015997i

Reference yield:

: 624-31-7
4-tolyl iodide

: 438193-74-9
4-(4-fluorophenyl)-2-(4-methoxybenzyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl)pyrazole-1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: i-PrMgCl / tetrahydrofuran / 0.25 h / -78 °C

1.2: ZnCl₂ / tetrahydrofuran / 0.75 h / -78 - 20 °C

1.3: 72 percent / Pd(PPh₃)4 / tetrahydrofuran / 10 h / 60 °C

2.1: 66 percent / K₃PO₄ / Pd(PPh₃)4 / H₂O; dioxane / 5 h / 90 °C

With potassium phosphate; isopropylmagnesium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jo015997i