4-(4-fluorophenyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl) 1-hydroxypyrazole

Base Information

Chemical Name:4-(4-fluorophenyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl) 1-hydroxypyrazole
CAS No.:438193-81-8
Molecular Formula:C₂₃H₁₉FN₂O₂
Molecular Weight:374.414
Hs Code.:

Synonyms:4-(4-fluorophenyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl) 1-hydroxypyrazole

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Chemical Property of 4-(4-fluorophenyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl) 1-hydroxypyrazole

Chemical Property:

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Technology Process of 4-(4-fluorophenyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl) 1-hydroxypyrazole

There total 6 articles about 4-(4-fluorophenyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl) 1-hydroxypyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 438193-74-9
4-(4-fluorophenyl)-2-(4-methoxybenzyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl)pyrazole-1-oxide

: 438193-81-8
4-(4-fluorophenyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl) 1-hydroxypyrazole

Guidance literature:: With chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane; for 24h; Heating;
DOI:10.1021/jo015997i

Reference yield:

: 624-31-7
4-tolyl iodide

: 438193-81-8
4-(4-fluorophenyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl) 1-hydroxypyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: i-PrMgCl / tetrahydrofuran / 0.25 h / -78 °C

1.2: ZnCl₂ / tetrahydrofuran / 0.75 h / -78 - 20 °C

1.3: 72 percent / Pd(PPh₃)4 / tetrahydrofuran / 10 h / 60 °C

2.1: 66 percent / K₃PO₄ / Pd(PPh₃)4 / H₂O; dioxane / 5 h / 90 °C

3.1: 68 percent / triisopropylsilane; trifluoroacetic acid / CH₂Cl₂ / 24 h / Heating

With potassium phosphate; chlorotriisopropylsilane; isopropylmagnesium chloride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jo015997i

Reference yield:

: 696-62-8
para-iodoanisole

: 438193-81-8
4-(4-fluorophenyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl) 1-hydroxypyrazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: i-PrMgCl / tetrahydrofuran / 0.5 h / 20 °C

1.2: ZnCl₂ / tetrahydrofuran / 0.5 h / 20 °C

1.3: 95 percent / Pd(PPh₃)4 / tetrahydrofuran / 3 h / 60 °C

2.1: 98 percent / NBS / acetonitrile / 4 h / 0 - 20 °C

3.1: i-PrMgCl / tetrahydrofuran / 0.25 h / -78 °C

3.2: ZnCl₂ / tetrahydrofuran / 0.75 h / -78 - 20 °C

3.3: 72 percent / Pd(PPh₃)4 / tetrahydrofuran / 10 h / 60 °C

4.1: 66 percent / K₃PO₄ / Pd(PPh₃)4 / H₂O; dioxane / 5 h / 90 °C

5.1: 68 percent / triisopropylsilane; trifluoroacetic acid / CH₂Cl₂ / 24 h / Heating

With potassium phosphate; N-Bromosuccinimide; chlorotriisopropylsilane; isopropylmagnesium chloride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;
DOI:10.1021/jo015997i