7-triethylsilyl-9-dihydro-13-acetylbaccatin III

Base Information

Chemical Name:7-triethylsilyl-9-dihydro-13-acetylbaccatin III
CAS No.:247244-56-0
Molecular Formula:C₃₉H₅₆O₁₂Si
Molecular Weight:744.952
Hs Code.:

Synonyms:7-triethylsilyl-9-dihydro-13-acetylbaccatin III

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Chemical Property of 7-triethylsilyl-9-dihydro-13-acetylbaccatin III

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Technology Process of 7-triethylsilyl-9-dihydro-13-acetylbaccatin III

There total 1 articles about 7-triethylsilyl-9-dihydro-13-acetylbaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 994-30-9
triethylsilyl chloride

: 142203-65-4
13-acetyl-9-dihydrobaccatin III

: 247244-56-0
7-triethylsilyl-9-dihydro-13-acetylbaccatin III

Guidance literature:: With pyridine; at 23 ℃; for 72h;
DOI:10.1016/S0968-0896(00)00056-0

Reference yield:

: 247244-56-0
7-triethylsilyl-9-dihydro-13-acetylbaccatin III

: 27548-93-2
baccatin III

Guidance literature:: Multi-step reaction with 4 steps

1: CrO₃; aq. H₂SO₄ / acetone / 0.5 h / 23 °C

2: 20 percent / lithium tri-tert-butoxyaluminohydride / tetrahydrofuran / 0.5 h / 4 °C

3: 29 percent / 1,8-diazabicyclo[5,4,0]undec-7-ene / toluene / 1.5 h / 80 °C

4: 48 percent / NaBH₄ / aq. phosphate buffer / 10 h / 23 °C / pH 7.0

With chromium(VI) oxide; sodium tetrahydroborate; lithium tri(t-butoxy)aluminum hydride; sulfuric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; phosphate buffer; acetone; toluene; 1: Jones' oxidation; desilylation / 2: Reduction / 3: Isomerization / 4: Deacetylation;
DOI:10.1016/S0968-0896(00)00056-0