(5-cyclohexyl-4-difluoromethyl-3,3,4-trifluoro-tetrahydro-furan-2-yloxy)-trimethyl-silane

Base Information

Chemical Name:(5-cyclohexyl-4-difluoromethyl-3,3,4-trifluoro-tetrahydro-furan-2-yloxy)-trimethyl-silane
CAS No.:220432-33-7
Molecular Formula:C₁₄H₂₃F₅O₂Si
Molecular Weight:346.413
Hs Code.:

Synonyms:(5-cyclohexyl-4-difluoromethyl-3,3,4-trifluoro-tetrahydro-furan-2-yloxy)-trimethyl-silane

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Chemical Property of (5-cyclohexyl-4-difluoromethyl-3,3,4-trifluoro-tetrahydro-furan-2-yloxy)-trimethyl-silane

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Technology Process of (5-cyclohexyl-4-difluoromethyl-3,3,4-trifluoro-tetrahydro-furan-2-yloxy)-trimethyl-silane

There total 4 articles about (5-cyclohexyl-4-difluoromethyl-3,3,4-trifluoro-tetrahydro-furan-2-yloxy)-trimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 220432-23-5
bromodifluoroacetaldehyde 1-cyclohexyl-2,3,3-trifluoro-2-propenyl O-(trimethylsilyl)acetal

: 220432-33-7
(5-cyclohexyl-4-difluoromethyl-3,3,4-trifluoro-tetrahydro-furan-2-yloxy)-trimethyl-silane

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 3h; Heating;
DOI:10.1021/jo982035b

Reference yield:

: 160016-76-2,223690-71-9
1-cyclohexyl-2,3,3-trifluoro-2-propenol

: 220432-33-7
(5-cyclohexyl-4-difluoromethyl-3,3,4-trifluoro-tetrahydro-furan-2-yloxy)-trimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) (COCl)2, 2.) Et₃N / 1.) Et₂O, 0 deg C, 1.5 h, 2.) Et₂O, 0 deg C, 1.5 h

2: 1.) DIBAL, 2.) pyridine / 1.) CH₂Cl₂, -78 deg C, 3 h, 2.) CH₂Cl₂, -78 deg C to 0 deg C, 6 h

3: 59 percent / AIBN, Bu₃SnH / benzene / 3 h / Heating

With pyridine; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; diisobutylaluminium hydride; triethylamine; In benzene;
DOI:10.1021/jo982035b

Reference yield:

: 220432-12-2
1-cyclohexyl-2,3,3-trifluoro-2-propenyl bromodifluoroacetate

: 220432-33-7
(5-cyclohexyl-4-difluoromethyl-3,3,4-trifluoro-tetrahydro-furan-2-yloxy)-trimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) DIBAL, 2.) pyridine / 1.) CH₂Cl₂, -78 deg C, 3 h, 2.) CH₂Cl₂, -78 deg C to 0 deg C, 6 h

2: 59 percent / AIBN, Bu₃SnH / benzene / 3 h / Heating

With pyridine; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; diisobutylaluminium hydride; In benzene;
DOI:10.1021/jo982035b