bromodifluoroacetaldehyde 1-cyclohexyl-2,3,3-trifluoro-2-propenyl O-(trimethylsilyl)acetal

Base Information

Chemical Name:bromodifluoroacetaldehyde 1-cyclohexyl-2,3,3-trifluoro-2-propenyl O-(trimethylsilyl)acetal
CAS No.:220432-23-5
Molecular Formula:C₁₄H₂₂BrF₅O₂Si
Molecular Weight:425.309
Hs Code.:

Synonyms:bromodifluoroacetaldehyde 1-cyclohexyl-2,3,3-trifluoro-2-propenyl O-(trimethylsilyl)acetal

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Chemical Property of bromodifluoroacetaldehyde 1-cyclohexyl-2,3,3-trifluoro-2-propenyl O-(trimethylsilyl)acetal

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Technology Process of bromodifluoroacetaldehyde 1-cyclohexyl-2,3,3-trifluoro-2-propenyl O-(trimethylsilyl)acetal

There total 3 articles about bromodifluoroacetaldehyde 1-cyclohexyl-2,3,3-trifluoro-2-propenyl O-(trimethylsilyl)acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 160016-76-2,223690-71-9
1-cyclohexyl-2,3,3-trifluoro-2-propenol

: 220432-23-5
bromodifluoroacetaldehyde 1-cyclohexyl-2,3,3-trifluoro-2-propenyl O-(trimethylsilyl)acetal

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) (COCl)2, 2.) Et₃N / 1.) Et₂O, 0 deg C, 1.5 h, 2.) Et₂O, 0 deg C, 1.5 h

2: 1.) DIBAL, 2.) pyridine / 1.) CH₂Cl₂, -78 deg C, 3 h, 2.) CH₂Cl₂, -78 deg C to 0 deg C, 6 h

With pyridine; oxalyl dichloride; diisobutylaluminium hydride; triethylamine;
DOI:10.1021/jo982035b

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 220432-23-5
bromodifluoroacetaldehyde 1-cyclohexyl-2,3,3-trifluoro-2-propenyl O-(trimethylsilyl)acetal

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, -100 deg C to -78 deg C, 1 h, 2.) THF, -78 deg C to 50 deg C, 1 h

2: 1.) (COCl)2, 2.) Et₃N / 1.) Et₂O, 0 deg C, 1.5 h, 2.) Et₂O, 0 deg C, 1.5 h

3: 1.) DIBAL, 2.) pyridine / 1.) CH₂Cl₂, -78 deg C, 3 h, 2.) CH₂Cl₂, -78 deg C to 0 deg C, 6 h

With pyridine; n-butyllithium; oxalyl dichloride; diisobutylaluminium hydride; triethylamine;
DOI:10.1021/jo982035b

Reference yield:

: 27607-77-8
trimethylsilyl trifluoromethanesulfonate

: 220432-12-2
1-cyclohexyl-2,3,3-trifluoro-2-propenyl bromodifluoroacetate

: 220432-23-5
bromodifluoroacetaldehyde 1-cyclohexyl-2,3,3-trifluoro-2-propenyl O-(trimethylsilyl)acetal

Guidance literature:: With pyridine; diisobutylaluminium hydride; Yield given; Multistep reaction; 1.) CH₂Cl₂, -78 deg C, 3 h, 2.) CH₂Cl₂, -78 deg C to 0 deg C, 6 h;
DOI:10.1021/jo982035b