5-n-butyl-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-4-<(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one

Base Information

Chemical Name:5-n-butyl-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-4-<(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one
CAS No.:170647-86-6
Molecular Formula:C₃₀H₃₁F₄N₅O₅S
Molecular Weight:649.666
Hs Code.:

Synonyms:5-n-butyl-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-4-<(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one

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Chemical Property of 5-n-butyl-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-4-<(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one

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Technology Process of 5-n-butyl-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-4-<(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one

There total 11 articles about 5-n-butyl-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-4-<(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 170647-85-5
5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-3H-1,2,4-triazol-3-one

: 170647-86-6
5-n-butyl-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-4-<(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one

Guidance literature:: With methoxybenzene; trifluoroacetic acid; Ambient temperature;
DOI:10.1021/jm00019a004

Reference yield:

: 51436-99-8
2-fluoro-4-bromotoluene

: 170647-86-6
5-n-butyl-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-4-<(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / aq. NaOH, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / ethanol / 4.5 h / 90 °C

2: Br₂ / CCl₄ / Heating; Irradiation

3: 1.) NaH / 1.) DMF, RT, 3.5 h, 2.) DMF, 35 deg C, 24 h

4: 62 percent / KF, CuI, KBr / dimethylformamide / 15 h / 120 °C

5: 91 percent / H₂ / PtO₂ / ethyl acetate; ethanol / 2 h / 1520 Torr

6: 88 percent / BOP, Et₃N / CH₂Cl₂ / Ambient temperature

7: 95 percent / TFA, anisole / Ambient temperature

With potassium fluoride; sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; bromine; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; methoxybenzene; triethylamine; trifluoroacetic acid; potassium bromide; platinum(IV) oxide; In tetrachloromethane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00019a004

Reference yield:

: 5133-68-6
ethyl N-carbethoxyvalerimidate

: 170647-86-6
5-n-butyl-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-4-<(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: 2.) Et₃N / 1.) THF, 65 deg C, 4 h, 2.) THF, 90 deg C, 20 h

2: 1.) NaH / 1.) DMF, RT, 3.5 h, 2.) DMF, 35 deg C, 24 h

3: 62 percent / KF, CuI, KBr / dimethylformamide / 15 h / 120 °C

4: 91 percent / H₂ / PtO₂ / ethyl acetate; ethanol / 2 h / 1520 Torr

5: 88 percent / BOP, Et₃N / CH₂Cl₂ / Ambient temperature

6: 95 percent / TFA, anisole / Ambient temperature

With potassium fluoride; copper(l) iodide; hydrogen; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; methoxybenzene; triethylamine; trifluoroacetic acid; potassium bromide; platinum(IV) oxide; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00019a004