C₁₄H₉ClN₄O

Base Information

• Chemical Name: C₁₄H₉ClN₄O
• CAS No.: 1264926-34-2
• Molecular Formula: C₁₄H₉ClN₄O
• Molecular Weight: 284.705
• Mol file: 1264926-34-2.mol

Synonyms:C₁₄H₉ClN₄O

Chemical Property of C₁₄H₉ClN₄O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₄H₉ClN₄O

There total 1 articles about C₁₄H₉ClN₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-cyanoindole-2-boronic acid (871329-64-5) + 4,6-dichloro-5-methoxypyrimidine (5018-38-2) → C14H9ClN4O (1264926-34-2)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; toluene; at 140 ℃; Inert atmosphere; in a pressure tube; microwave reactor;

Reference yield:

C14H9ClN4O (1264926-34-2) + 4-methylphenylboronic acid (5720-05-8) → 2-[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]-1H-indole-5-carbonitrile (1264924-22-2)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; toluene; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

C14H9ClN4O (1264926-34-2) → 4-[5-(aminomethyl)-1H-indol-2-yl]-6-(4-methylphenyl)-5-pyrimidinol (1264924-26-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; 1,2-dimethoxyethane; water / 16 h / 100 °C / Inert atmosphere

2: lithium iodide / quinoline / 0.17 h / 200 °C / Inert atmosphere; sealed in a pressure tube; microwave reactor

3: hydrogen; ammonia / Raney Ni / methanol / 50 °C / 3102.97 Torr / sealed in a pressure tube

With ammonia; hydrogen; potassium carbonate; lithium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In quinoline; methanol; 1,2-dimethoxyethane; water; toluene;

upstream raw materials:

5-cyanoindole-2-boronic acid

4,6-dichloro-5-methoxypyrimidine

Downstream raw materials:

2-[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]-1H-indole-5-carbonitrile

4-[5-(aminomethyl)-1H-indol-2-yl]-6-(4-methylphenyl)-5-pyrimidinol

C₂₀H₁₄N₄O