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Usage

Uses

Used in Organic Synthesis:
5-CYANO-1H-INDOLE-2-BORONIC ACID is used as a reagent in organic synthesis for the creation of various biologically active compounds. Its boronic acid functional group plays a crucial role in facilitating Suzuki-Miyaura cross-coupling reactions, which are essential for the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5-CYANO-1H-INDOLE-2-BORONIC ACID is utilized as a key component in the development of new pharmaceuticals. Its ability to interact with biological targets and modulate their activity makes it a promising candidate for the treatment of various diseases.
Used in Pharmaceutical Industry:
5-CYANO-1H-INDOLE-2-BORONIC ACID is used as a building block in the pharmaceutical industry for the synthesis of drugs targeting diseases such as cancer and diabetes. Its potential therapeutic applications are currently under investigation, with the aim of developing effective treatments that can modulate the activity of specific biological targets.
Used in Drug Discovery:
5-CYANO-1H-INDOLE-2-BORONIC ACID is employed as a versatile chemical in drug discovery, where it contributes to the identification and development of novel therapeutic agents. Its unique properties and reactivity in chemical reactions make it an important tool in the search for new drugs to combat various diseases.

Upstream product

• 475102-10-4 1-(tert-butoxycarbonyl)-1H-indole-5-carbonitrile 

Downstream Products

• 1264926-36-4 C₂₀H₁₄N₄O 
• 1264924-26-6 4-[5-(aminomethyl)-1H-indol-2-yl]-6-(4-methylphenyl)-5-pyrimidinol 
• 1264924-22-2 2-[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]-1H-indole-5-carbonitrile 
• 1264926-34-2 C₁₄H₉ClN₄O 

Relevant academic research and scientific papers

Novel indole derivatives, preparation thereof as medicinal products and pharmaceutical compositions, and especially as KDR inhibitors

The invention relates to compounds of formula (I): in which R1 represents pyrazolyl or indazolyl, R2 and R3 especially represent H, halogen, hydroxyl, nitro, cyano, R4, —OR4, —COR4, —OC(═O)R4, —C(═O)OR4, —C(═O)OH, —N(R5)C(═O)R4, —N(R5)C(═O)OR4, —S(O)nR4, —S(O)nOR4, —N(R5)SO2R4, —NY1Y2, —C(═O)NY1Y2, —N(R5)C(═O)NY1Y2, —S(O)nNY1Y2 and —OC(═O)NY1Y2, R4 especially represents alkyl, alkenyl, cycloalkyl, aryl, heteroaryl and heterocycloalkyl, R5 especially represents H, alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, Y1 and Y2 especially represent H, alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, arylcarboxyl, heteroaryl and heteroarylcarboxy, which are optionally substituted, or Y1 and Y2 form with N an amino ring, n represents 0 to 2, all these radicals being optionally substituted, these products being in all the isomeric forms and the salts, as medicinal products, especially as KDR inhibitors.