Technology Process of tert-butyl 4-(4-(4-hydroxy-4'-(trifluoromethyl)biphenyl-3-yl)pyridin-2-yl)piperazine-1-carboxylate
There total 6 articles about tert-butyl 4-(4-(4-hydroxy-4'-(trifluoromethyl)biphenyl-3-yl)pyridin-2-yl)piperazine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
10 wt% Pd(OH)2 on carbon;
In
ethanol;
at 60 ℃;
for 18h;
under 2585.81 Torr;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate; tetra(n-butyl)ammonium hydroxide / tri tert-butylphosphoniumtetrafluoroborate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide / N,N-dimethyl-formamide; methanol / 3 h / 130 °C / Microwave irradiation; Sealed tube
2: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 18 h / 60 °C / 2585.81 Torr
With
tetra(n-butyl)ammonium hydroxide; hydrogen; potassium carbonate;
bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide; 10 wt% Pd(OH)2 on carbon; tri tert-butylphosphoniumtetrafluoroborate;
In
methanol; ethanol; N,N-dimethyl-formamide;
1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 18 h / 70 °C / Inert atmosphere
2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere
2.2: 18 h / 60 °C
3.1: potassium carbonate; tetra(n-butyl)ammonium hydroxide / tri tert-butylphosphoniumtetrafluoroborate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide / N,N-dimethyl-formamide; methanol / 3 h / 130 °C / Microwave irradiation; Sealed tube
4.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 18 h / 60 °C / 2585.81 Torr
With
tetra(n-butyl)ammonium hydroxide; hydrogen; sodium carbonate; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0); bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide; 10 wt% Pd(OH)2 on carbon; tri tert-butylphosphoniumtetrafluoroborate;
In
1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;
1.1: Suzuki Coupling / 3.1: Suzuki Coupling;
