tert-butyl 4-(4-(4-hydroxy-4'-(trifluoromethyl)biphenyl-3-yl)pyridin-2-yl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(4-hydroxy-4'-(trifluoromethyl)biphenyl-3-yl)pyridin-2-yl)piperazine-1-carboxylate
CAS No.:1354787-46-4
Molecular Formula:C₂₇H₂₈F₃N₃O₃
Molecular Weight:499.533
Hs Code.:

Synonyms:tert-butyl 4-(4-(4-hydroxy-4'-(trifluoromethyl)biphenyl-3-yl)pyridin-2-yl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(4-hydroxy-4'-(trifluoromethyl)biphenyl-3-yl)pyridin-2-yl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(4-hydroxy-4'-(trifluoromethyl)biphenyl-3-yl)pyridin-2-yl)piperazine-1-carboxylate

There total 6 articles about tert-butyl 4-(4-(4-hydroxy-4'-(trifluoromethyl)biphenyl-3-yl)pyridin-2-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1354787-47-5
tert-Butyl 4-(4-(4-(benzyloxy)-4'-(trifluoromethyl)biphenyl-3-yl)pyridin-2-yl)piperazine-1-carboxylate

: 1354787-46-4
tert-butyl 4-(4-(4-hydroxy-4'-(trifluoromethyl)biphenyl-3-yl)pyridin-2-yl)piperazine-1-carboxylate

Guidance literature:: With hydrogen; 10 wt% Pd(OH)2 on carbon; In ethanol; at 60 ℃; for 18h; under 2585.81 Torr;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1354787-46-4
tert-butyl 4-(4-(4-hydroxy-4'-(trifluoromethyl)biphenyl-3-yl)pyridin-2-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; tetra(n-butyl)ammonium hydroxide / tri tert-butylphosphoniumtetrafluoroborate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide / N,N-dimethyl-formamide; methanol / 3 h / 130 °C / Microwave irradiation; Sealed tube

2: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 18 h / 60 °C / 2585.81 Torr

With tetra(n-butyl)ammonium hydroxide; hydrogen; potassium carbonate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide; 10 wt% Pd(OH)2 on carbon; tri tert-butylphosphoniumtetrafluoroborate; In methanol; ethanol; N,N-dimethyl-formamide; 1: Suzuki Coupling;

Reference yield:

: 89488-25-5
(5‐chloro‐2‐hydroxyphenyl)boronic acid

: 1354787-46-4
tert-butyl 4-(4-(4-hydroxy-4'-(trifluoromethyl)biphenyl-3-yl)pyridin-2-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 70 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

2.2: 18 h / 60 °C

3.1: potassium carbonate; tetra(n-butyl)ammonium hydroxide / tri tert-butylphosphoniumtetrafluoroborate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide / N,N-dimethyl-formamide; methanol / 3 h / 130 °C / Microwave irradiation; Sealed tube

4.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 18 h / 60 °C / 2585.81 Torr

With tetra(n-butyl)ammonium hydroxide; hydrogen; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide; 10 wt% Pd(OH)2 on carbon; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; 1.1: Suzuki Coupling / 3.1: Suzuki Coupling;