89488-25-5

Basic information

• Product Name: 5-CHLORO-2-HYDROXYPHENYLBORONIC ACID
• Synonyms: AKOS BRN-0742;5-CHLORO-2-HYDROXYPHENYLBORONIC ACID;5-CHLORO-2-HYDROXYBENZENEBORONIC ACID;5-Chloro-2-hydroxybenzeneboronic acid 97%;2-Borono-4-chlorophenol;Benzeneboronic acid, 5-chloro-2-hydroxy-;Boronic acid, B-(5-chloro-2-hydroxyphenyl)-;5-Chloro-2-hydroxybenzeneboronicacid97%
• CAS NO: 89488-25-5
• Molecular Formula: C₆H₆BClO₃
• Molecular Weight: 172.37
• Product Categories: blocks;BoronicAcids;Boronate Ester;Boronic Acid;Potassium Trifluoroborate
• Mol File: 89488-25-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 166-170
• Boiling Point: 369.275 °C at 760 mmHg
• Flash Point: 177.131 °C
• Appearance: /
• Density: 1.492g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.63±0.58(Predicted)
• CAS DataBase Reference: 5-CHLORO-2-HYDROXYPHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-HYDROXYPHENYLBORONIC ACID(89488-25-5)
• EPA Substance Registry System: 5-CHLORO-2-HYDROXYPHENYLBORONIC ACID(89488-25-5)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 89488-25-5(Hazardous Substances Data)

Usage

Uses

suzuki reaction

InChI:InChI=1/C6H6BClO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9-11H

Upstream product

• 106-48-9 4-chloro-phenol 
• 121-43-7 Trimethyl borate 
• 826-26-6 1-chloro-4-(methoxymethoxy)benzene 
• 7732-18-5 water 
• 89694-48-4 5-chloro-2-methoxyphenyl boronic acid 
• 89466-08-0 2-hydroxyphenyl boronic acid 

Downstream Products

• 1426336-63-1 (S)-6-((1-amino-1-oxopropan-2-yl)amino)-2-(2-(2-aminopyridin-4-yl)-4-chlorophenoxy)pyrimidine-4-carboxamide 
• 1567216-51-6 (S,E)-methyl 2-(7-(4-(buta-1,3-dien-1-yl)-4-methylpiperidin-1-yl)-2-(5‘-chloro-2‘-hydroxy-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1354818-78-2 5-chloro-4-[4-chloro-2-(2-piperazin-1-ylpyrimidin-4-yl)phenoxy]-2-fluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide trifluoroacetate 
• 1354818-76-0 5-chloro-4-[4-chloro-2-(2-piperazin-1-ylpyrimidin-4-yl)phenoxy]-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide trifluoroacetate 
• 1354819-01-4 4-[4-chloro-2-(2-piperazin-1-ylpyrimidin-4-yl)phenoxy]-2,5-difluoro-N-1,3-thiazol-4-ylbenzenesulfonamide trifluoroacetate 
• 1354818-90-8 4-[2-(2-aminopyridin-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide 
• 1354819-12-7 C₂₅H₂₁Cl₂FN₄O₅S₂ 
• 1354818-89-5 4-[2-(2-aminopyridin-4-yl)-4-chlorophenoxy]-3-chloro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide trifluoroacetate 
• 1354819-10-5 C₂₈H₂₃Cl₂N₅O₅S₂ 
• 1235407-36-9 tert-butyl 4-[4-(5-chloro-2-hydroxyphenyl)pyrimidin-2-yl]piperazine-1-carboxylate 
• 1354819-18-3 4-[2-(2-aminopyridin-4-yl)-4-chlorophenoxy]-5-chloro-N-(ethoxymethyl)-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide 

Relevant articles and documents

Enantiodivergent Atroposelective Synthesis of Chiral Biaryls by Asymmetric Transfer Hydrogenation: Chiral Phosphoric Acid Catalyzed Dynamic Kinetic Resolution

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Rh/Pd catalysis with chiral and achiral ligands: Domino synthesis of aza-dihydrodibenzoxepines

A game of dominoes: A synthetic route to aza-dihydrodibenzoxepines is described, through the combination of a Rh-catalyzed arylation and a Pd-catalyzed C-O coupling in a single pot. For the first time, the ability to incorporate a chiral and an achiral ligand in a two-component, two-metal transformation is achieved, giving the products in moderate to good yields, with excellent enantioselectivities. Copyright