1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile

Base Information

Chemical Name:1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile
CAS No.:1542705-83-8
Molecular Formula:C₂₄H₂₁N₅O
Molecular Weight:395.464
Hs Code.:

Synonyms:1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile

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Chemical Property of 1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile

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Technology Process of 1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile

There total 14 articles about 1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1360883-22-2
2-methyl-1H-indole-4-carbonitrile

: 1542711-55-6
N-benzyl-2-chloro-7,8-di-hydro-5H-pyrano[4,3-d]pyrimidin-4-amine

: 1542705-83-8
1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In 1,4-dioxane; for 12h; Inert atmosphere; Heating;
DOI:10.1016/j.bmc.2018.12.036

Reference yield:

: 127956-11-0
4-oxotetrahydro-2H-pyran-3-carboxylic acid methyl ester

: 1542705-83-8
1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate / methanol / 20 °C

2.1: acetonitrile / 0.5 h

2.2: 70 °C

3.1: trichlorophosphate / 2 h / Reflux

4.1: acetonitrile / 20 °C

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; caesium carbonate / 1,4-dioxane / 2 h / 100 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ammonium acetate; caesium carbonate; XPhos; trichlorophosphate; In 1,4-dioxane; methanol; acetonitrile;

Reference yield:

: 1542711-49-8
methyl 4-amino-5,6-dihydro-2H-pyran-3-carboxylate

: 1542705-83-8
1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetonitrile / 0.5 h

1.2: 70 °C

2.1: trichlorophosphate / 2 h / Reflux

3.1: acetonitrile / 20 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; caesium carbonate / 1,4-dioxane / 2 h / 100 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; trichlorophosphate; In 1,4-dioxane; acetonitrile;