4-Cyano-2-Methyl-1H-indole

Base Information

• Chemical Name: 4-Cyano-2-Methyl-1H-indole
• CAS No.: 1360883-22-2
• Molecular Formula: C10H8N2
• Molecular Weight: 156.187
• Hs Code.: 2933998090
• Mol file: 1360883-22-2.mol

Synonyms:4-Cyano-2-Methyl-1H-indole;2-methyl-1H-indole-4-carbonitrile;1H-Indole-4-carbonitrile, 2-methyl-

Chemical Property of 4-Cyano-2-Methyl-1H-indole

Chemical Property:

• Boiling Point: 353.9±22.0 °C(Predicted)
• PKA: 15.74±0.30(Predicted)
• PSA: 39.58000
• Density: 1.20±0.1 g/cm3(Predicted)
• LogP: 2.34798
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

2-Methyl-1H-indole-4-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Cyano-2-Methyl-1H-indole

There total 12 articles about 4-Cyano-2-Methyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

zinc cyanide + 4-bromo-2-methyl-1H-indole (6127-18-0) → 2-methyl-1H-indole-4-carbonitrile (1360883-22-2)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; zinc; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 18h; Inert atmosphere;

Reference yield: 90.0%

2-methyl-1-(phenylsulfonyl)-1H-indole-4-carbonitrile → 2-methyl-1H-indole-4-carbonitrile (1360883-22-2)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 40 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmc.2018.12.036

Reference yield: 77.0%

1-(phenylsulfonyl)-1H-indole-4-carbonitrile + methyl iodide (74-88-4) → 2-methyl-1H-indole-4-carbonitrile (1360883-22-2)

Guidance literature:

1-(phenylsulfonyl)-1H-indole-4-carbonitrile; With n-butyllithium; In tetrahydrofuran; hexane; at -40 ℃; for 1h; Schlenk technique; Inert atmosphere;

methyl iodide; In tetrahydrofuran; hexane; at -40 - 20 ℃; Schlenk technique; Inert atmosphere;

With sodium hydroxide; In ethanol; at 40 ℃; for 3h; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.202103133

upstream raw materials:

4-bromo-2-methyl-1H-indole

1-(2-bromophenyl)propane-2-one

2-(2-bromophenyl)-3-methyl-2H-azirine

4-cyanoindole

Downstream raw materials:

1-(4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile

1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide

1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile

1-(4-(benzylamino)-5,6,7,8-tetrahydroquinazolin-2-yl)-2-methyl-1H-indole-4-carboxamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1360883-22-2 4-Cyano-2-Methyl-1H-indole

Send

Send

Metric Ton KG G Pound L ML

Send

Send