2-n-butyl-1-(4-carbomethoxy-3-methoxymethoxyphenyl)methyl-4-chloro-1H-imidazol-5-carboxaldehyde

Base Information

Chemical Name:2-n-butyl-1-(4-carbomethoxy-3-methoxymethoxyphenyl)methyl-4-chloro-1H-imidazol-5-carboxaldehyde
CAS No.:149543-78-2
Molecular Formula:C₁₉H₂₃ClN₂O₅
Molecular Weight:394.855
Hs Code.:

Synonyms:2-n-butyl-1-(4-carbomethoxy-3-methoxymethoxyphenyl)methyl-4-chloro-1H-imidazol-5-carboxaldehyde

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Chemical Property of 2-n-butyl-1-(4-carbomethoxy-3-methoxymethoxyphenyl)methyl-4-chloro-1H-imidazol-5-carboxaldehyde

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Technology Process of 2-n-butyl-1-(4-carbomethoxy-3-methoxymethoxyphenyl)methyl-4-chloro-1H-imidazol-5-carboxaldehyde

There total 1 articles about 2-n-butyl-1-(4-carbomethoxy-3-methoxymethoxyphenyl)methyl-4-chloro-1H-imidazol-5-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83857-96-9
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde

: 149543-77-1
methyl 4-bromomethyl-2-methoxymethoxybenzoate

: 149543-78-2
2-n-butyl-1-(4-carbomethoxy-3-methoxymethoxyphenyl)methyl-4-chloro-1H-imidazol-5-carboxaldehyde

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 1h;
DOI:10.1021/jm00065a011

Reference yield:

: 149543-78-2
2-n-butyl-1-(4-carbomethoxy-3-methoxymethoxyphenyl)methyl-4-chloro-1H-imidazol-5-carboxaldehyde

: 149543-79-3
2-n-butyl-1-(4-carbomethoxy-3-methoxymethoxyphenyl)-methyl-1H-imidazol-5-carboxaldehyde

Guidance literature:: With manganese(IV) oxide; hydrogen; potassium acetate; palladium on activated charcoal; Multistep reaction; 1.) MeOH, 40 psi, 1.25 h, 2.) CH₂Cl₂, reflux;
DOI:10.1021/jm00065a011

Reference yield:

: 149543-78-2
2-n-butyl-1-(4-carbomethoxy-3-methoxymethoxyphenyl)methyl-4-chloro-1H-imidazol-5-carboxaldehyde

: 149543-81-7
methyl (E)-3-[2-n-butyl-1-{(4-carbomethoxy-3-hydroxyphenyl)methyl}-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenoate

Guidance literature:: Multi-step reaction with 5 steps

1: manganese(IV) oxide; hydrogen; potassium acetate / palladium on activated charcoal / 1.) MeOH, 40 psi, 1.25 h, 2.) CH₂Cl₂, reflux

2: lithium diisopropyl amide / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min

3: dmap / dichloromethane / 19 h

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 1 h / 100 °C

5: hydrogenchloride / methanol

With hydrogenchloride; dmap; manganese(IV) oxide; hydrogen; potassium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; palladium on activated charcoal; In methanol; dichloromethane; toluene;
DOI:10.1021/jm00065a011