4-(8-amino-3-((3R,7R,9aS)-3-methyl-4-oxooctahydropyrido[2,1-c][1,4]oxazin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Base Information

Chemical Name:4-(8-amino-3-((3R,7R,9aS)-3-methyl-4-oxooctahydropyrido[2,1-c][1,4]oxazin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide
CAS No.:1620673-97-3
Molecular Formula:C₂₈H₂₆F₃N₇O₃
Molecular Weight:565.555
Hs Code.:

Synonyms:4-(8-amino-3-((3R,7R,9aS)-3-methyl-4-oxooctahydropyrido[2,1-c][1,4]oxazin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

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Chemical Property of 4-(8-amino-3-((3R,7R,9aS)-3-methyl-4-oxooctahydropyrido[2,1-c][1,4]oxazin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

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Technology Process of 4-(8-amino-3-((3R,7R,9aS)-3-methyl-4-oxooctahydropyrido[2,1-c][1,4]oxazin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

There total 11 articles about 4-(8-amino-3-((3R,7R,9aS)-3-methyl-4-oxooctahydropyrido[2,1-c][1,4]oxazin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418307-30-8
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-N-(4-trifluoromethyl-pyridin-2-yl)-benzamide

: 1620676-30-3
(3R,7R,9aS)-7-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)-3-methylhexahydropyrido[2,1-c][1,4]oxazin-4(3H)-one

: 1620673-97-3
4-(8-amino-3-((3R,7R,9aS)-3-methyl-4-oxooctahydropyrido[2,1-c][1,4]oxazin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 90 - 100 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 1620676-39-2
(3R,7R,9aS)-7-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)-3-methylhexahydropyrido[2,1-c][1,4]oxazin-4(3H)-one

: 1620673-97-3
4-(8-amino-3-((3R,7R,9aS)-3-methyl-4-oxooctahydropyrido[2,1-c][1,4]oxazin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide / isopropyl alcohol / 12 h / 100 °C / Sealed tube

2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 1.5 h / 90 - 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium hydroxide; potassium carbonate; In 1,4-dioxane; water; isopropyl alcohol;

Reference yield:

: 1620676-31-4
(3R,6S)-methyl 6-(((tert-butyldimethylsilyl)oxy)methyl)piperidine-3-carboxylate

: 1620673-97-3
4-(8-amino-3-((3R,7R,9aS)-3-methyl-4-oxooctahydropyrido[2,1-c][1,4]oxazin-7-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / dichloromethane / 0.67 h / 0 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

4.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

4.2: pH 3-4

5.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 0 °C

5.2: 12 h / 0 - 15 °C / Inert atmosphere

6.1: trichlorophosphate; pyridine; N,N-dimethyl-formamide / dichloromethane / 5 h / 0 °C

7.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1.5 h / 10 °C / Inert atmosphere

8.1: ammonium hydroxide / isopropyl alcohol / 12 h / 100 °C / Sealed tube

9.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 1.5 h / 90 - 100 °C / Inert atmosphere

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium hydroxide; N-Bromosuccinimide; oxalyl dichloride; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; sodium hydride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;