4-AMINO-1-N-BUTOXYCARBONYL-4-ETHYL-PIPERIDINE

Base Information

• Chemical Name: 4-AMINO-1-N-BUTOXYCARBONYL-4-ETHYL-PIPERIDINE
• CAS No.: 741687-07-0
• Molecular Formula: C12H24N2O2
• Molecular Weight: 228.335
• Hs Code.: 2933399090
• Mol file: 741687-07-0.mol

Synonyms:tert-Butyl4-amino-4-ethylpiperidine-1-carboxylate;4-Amino-1-n-butoxycarbonyl-4-ethyl-piperidine;

Chemical Property of 4-AMINO-1-N-BUTOXYCARBONYL-4-ETHYL-PIPERIDINE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.475
• Boiling Point: 300.561 °C at 760 mmHg
• Flash Point: 135.575 °C
• PSA: 55.56000
• Density: 1 g/cm³
• LogP: 2.76460
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-Amino-4-ethylpiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-1-N-BUTOXYCARBONYL-4-ETHYL-PIPERIDINE

There total 9 articles about 4-AMINO-1-N-BUTOXYCARBONYL-4-ETHYL-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

C13H24N2O3 → tert-butyl 4-amino-4-ethylpiperidine-1-carboxylate (741687-07-0)

Guidance literature:

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium hydroxide; In acetonitrile; at 20 ℃;

Reference yield:

4-ethyl-4-isocyanato-piperidine-1-carboxylic acid tert-butyl ester → tert-butyl 4-amino-4-ethylpiperidine-1-carboxylate (741687-07-0)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/j.bmcl.2004.05.014

Reference yield:

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate (124443-68-1) → tert-butyl 4-amino-4-ethylpiperidine-1-carboxylate (741687-07-0)

Guidance literature:

Multi-step reaction with 6 steps

1: LDA / tetrahydrofuran / -78 °C

2: KOH / methanol / Heating

3: NMM / tetrahydrofuran / 1 h / -15 °C

4: aq. NaN₃ / tetrahydrofuran / -15 - 20 °C

5: toluene / 1.5 h / 90 °C

6: aq. KOH / tetrahydrofuran / 0 °C

With 4-methyl-morpholine; potassium hydroxide; sodium azide; lithium diisopropyl amide; In tetrahydrofuran; methanol; toluene; 5: Curtius rearrangement;

DOI:10.1016/j.bmcl.2004.05.014

upstream raw materials:

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

1-tert-butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate

1-(tert-butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid

tert-butyl 4-cyano-4-ethylpiperidine-1-carboxylate