1-BOC-4-ETHYL-4-PIPERIDINECARBOXYLIC ACID

Base Information

• Chemical Name: 1-BOC-4-ETHYL-4-PIPERIDINECARBOXYLIC ACID
• CAS No.: 188792-67-8
• Molecular Formula: C13H23 N O4
• Molecular Weight: 257.33
• Hs Code.: 2933399090
• Mol file: 188792-67-8.mol

Synonyms:1-(tert-Butoxycarbonyl)-4-ethylpiperidine-4-carboxylicacid

Chemical Property of 1-BOC-4-ETHYL-4-PIPERIDINECARBOXYLIC ACID

Chemical Property:

• PSA: 66.84000
• LogP: 2.43620

Purity/Quality:

97% ^*data from raw suppliers

1-(tert-Butoxycarbonyl)-4-ethylpiperidine-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-4-ETHYL-4-PIPERIDINECARBOXYLIC ACID

There total 6 articles about 1-BOC-4-ETHYL-4-PIPERIDINECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

1-tert-butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate (578021-55-3) → 1-(tert-butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid (188792-67-8)

Guidance literature:

With water; potassium hydroxide; In methanol; at 70 ℃; for 19h;

Reference yield: 45.0%

ethyl 1-boc-4-ethyl-4-piperidine carboxylate (188792-70-3) → 1-(tert-butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid (188792-67-8)

Guidance literature:

With lithium hydroxide; In ethanol; water;

Reference yield:

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate (124443-68-1) → 1-(tert-butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid (188792-67-8)

Guidance literature:

Multi-step reaction with 2 steps

1: LDA / tetrahydrofuran / -78 °C

2: KOH / methanol / Heating

With potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2004.05.014

upstream raw materials:

1-tert-butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

ethyl 1-boc-4-ethyl-4-piperidine carboxylate

4-carbethoxypiperidine

Downstream raw materials:

tert-butyl 4-amino-4-ethylpiperidine-1-carboxylate

tert-butyl 4-isocyanato-4-methylpiperidine-1-carboxylate

4-ethylpiperidine-4-carboxylic acid

1-tert-butyl 4-ethyl 4-[2-(3-cyano-4-fluorophenyl)ethyl]piperidine-1,4-dicarboxylate