2H-Pyran,tetrahydro-3-(1-methylethyl)-2-(2-propenyl)-,(2R,3S)-rel-(9CI)

Base Information

• Chemical Name: 2H-Pyran,tetrahydro-3-(1-methylethyl)-2-(2-propenyl)-,(2R,3S)-rel-(9CI)
• CAS No.: 645413-27-0
• Molecular Formula: C₁₁H₂₀O
• Molecular Weight: 168.279
• Mol file: 645413-27-0.mol

Synonyms:2H-Pyran,tetrahydro-3-(1-methylethyl)-2-(2-propenyl)-, (2R,3S)-rel- (9CI)

Chemical Property of 2H-Pyran,tetrahydro-3-(1-methylethyl)-2-(2-propenyl)-,(2R,3S)-rel-(9CI)

Chemical Property:

• Boiling Point: 224.4 °C at 760 mmHg
• Flash Point: 80.4 °C
• PSA: 9.23000
• Density: 0.882 g/cm³
• LogP: 3.01370
• Water Solubility.: at 25 deg C (mg/L): 63.27

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Pyran,tetrahydro-3-(1-methylethyl)-2-(2-propenyl)-,(2R,3S)-rel-(9CI)

There total 12 articles about 2H-Pyran,tetrahydro-3-(1-methylethyl)-2-(2-propenyl)-,(2R,3S)-rel-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

allyl-trimethyl-silane (762-72-1) + 3-isopropyltetrahydropyran-2-acetate (645413-24-7) → cis-2-allyl-3-isopropyltetrahydropyran (645413-27-0,645413-28-1) + trans-2-allyl-3-isopropyltetrahydropyran (645413-27-0,645413-28-1)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -78 - 23 ℃;

DOI:10.1021/ja037935a

Reference yield:

allyl-trimethyl-silane (762-72-1) + 3-isopropyltetrahydropyran-2-acetate (645413-24-7) → cis-2-allyl-3-isopropyltetrahydropyran (645413-27-0,645413-28-1) + trans-2-allyl-3-isopropyltetrahydropyran (645413-27-0,645413-28-1)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -78 - 23 ℃;

DOI:10.1021/ja037935a

Reference yield:

3-isopropyltetrahydropyran-2-one (32821-70-8) → cis-2-allyl-3-isopropyltetrahydropyran (645413-27-0,645413-28-1)

Guidance literature:

Multi-step reaction with 3 steps

1: DIBAL-H / CH₂Cl₂; toluene / 5 h / -78 °C

2: 0.196 g / pyridine; 4-dimethylaminopyridine / toluene; tetrahydrofuran / -78 - 23 °C

3: 0.080 g / BF₃*OEt₂ / CH₂Cl₂ / -78 - 23 °C

With pyridine; dmap; boron trifluoride diethyl etherate; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/ja037935a

upstream raw materials:

allyl-trimethyl-silane

3-isopropyltetrahydropyran-2-acetate

3-isopropyltetrahydropyran-2-one

Ethyl isovalerate