1-(3-(6-methoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)ethanone

Base Information

Chemical Name:1-(3-(6-methoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)ethanone
CAS No.:1443828-30-5
Molecular Formula:C₂₇H₂₇NO₅
Molecular Weight:445.515
Hs Code.:

Synonyms:1-(3-(6-methoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)ethanone

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Chemical Property of 1-(3-(6-methoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)ethanone

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Technology Process of 1-(3-(6-methoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)ethanone

There total 6 articles about 1-(3-(6-methoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 586-42-5
3-acetylbenzoic acid

: 1443828-06-5
6-methoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline

: 1443828-30-5
1-(3-(6-methoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)ethanone

Guidance literature:: 3-acetylbenzoic acid; With dmap; 1,2-dichloro-ethane; In dichloromethane; at 0 ℃; for 2h;

6-methoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/jm400177t

Reference yield:

: 2039-67-0
2-(3-methoxyphenyl)-1-ethanamine

: 1443828-30-5
1-(3-(6-methoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0 °C

2.1: trichlorophosphate / toluene / 1.5 h / Reflux

3.1: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C / Inert atmosphere

4.1: 1,2-dichloro-ethane; dmap / dichloromethane / 2 h / 0 °C

4.2: 18 h / 20 °C

With dmap; sodium tetrahydroborate; 1,2-dichloro-ethane; triethylamine; trichlorophosphate; In methanol; dichloromethane; toluene;
DOI:10.1021/jm400177t

Reference yield:

: 1443827-91-5
C₁₈H₁₉NO₃

: 1443828-30-5
1-(3-(6-methoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C / Inert atmosphere

2.1: 1,2-dichloro-ethane; dmap / dichloromethane / 2 h / 0 °C

2.2: 18 h / 20 °C

With dmap; sodium tetrahydroborate; 1,2-dichloro-ethane; In methanol; dichloromethane;
DOI:10.1021/jm400177t