(-)-NOE'S REAGENT

Base Information

• Chemical Name: (-)-NOE'S REAGENT
• CAS No.: 108031-79-4
• Molecular Formula: C₂₄H₃₈O₃
• Molecular Weight: 374.564
• Mol file: 108031-79-4.mol

Synonyms:4,7-methanobenzofuran, 2,2'-oxybis[octahydro-7,8,8-trimethyl-, (2S,3aR,4S,7S,7aR,2'S,3'aR,4'S,7'S,7'aR)-;(-)-Noe-lactol dimer;(2S,3aR,4S,7S,7aR,2'S,3a'R,4'S,7'S,7a'R)-2,2'-Oxybis(7,8,8-trimethyloctahydro-4,7-methano-1-benzofuran;(-)-Noe's reagent;

Chemical Property of (-)-NOE'S REAGENT

Chemical Property:

• Melting Point: 150-154 °C(lit.)
• Refractive Index: -202.5 ° (C=2, THF)
• Boiling Point: 435.9 °C at 760 mmHg
• Flash Point: 148.7 °C
• PSA: 27.69000
• Density: 1.12 g/cm³
• LogP: 5.37760
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(-)-Noe’sReagent ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F
• Hazard Codes: F
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (-)-NOE'S REAGENT

There total 4 articles about (-)-NOE'S REAGENT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3aR-(3aα,4β,7β,7aα))-3a,4,5,6,7,7a-Hexahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2(3H)-on (81969-33-7) → C24H38O3 (81955-10-4,87248-50-8,108031-77-2,108031-78-3,108031-79-4,108031-80-7,108031-81-8,108032-85-5)

Guidance literature:

Multi-step reaction with 2 steps

1: (iBu)2AlH

2: acid

With diisobutylaluminium hydride;

Reference yield:

<2R-(2α,3aα,4β,7β,7aα)>-Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-ol (108031-76-1) + (1S,2R,4R,6R,7S)-1,10,10-Trimethyl-3-oxa-tricyclo[5.2.1.02,6]decan-4-ol (108031-75-0) → (2S,2'S-(2α,2'α,3aα,3a'α,4β,4'β,7β,7'β,7aα,7a'α))-2,2'-oxybis[octahydro-7,8,8-trimethyl-4,7-methanobenzofuran] (108031-80-7) + C24H38O3 (81955-10-4,87248-50-8,108031-77-2,108031-78-3,108031-79-4,108031-80-7,108031-81-8,108032-85-5) + 2S-<2α(2'R*,3'aS*,4'S*,7'S*,7'aS*),3aα,4α,7α,7aα>-2,2'-Oxybis (108032-85-5)

Guidance literature:

With acid;

Reference yield:

(1S,2R,4R,6R,7S)-1,10,10-Trimethyl-3-oxa-tricyclo[5.2.1.02,6]decan-4-ol (81925-09-9,108031-74-9,108031-75-0,108031-76-1) → C24H38O3 (81955-10-4,87248-50-8,108031-77-2,108031-78-3,108031-79-4,108031-80-7,108031-81-8,108032-85-5) + C24H38O3

Guidance literature:

upstream raw materials:

<2R-(2α,3aα,4β,7β,7aα)>-Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-ol

(1S,2R,4R,6R,7S)-1,10,10-Trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]decan-4-ol

(3aR-(3aα,4β,7β,7aα))-3a,4,5,6,7,7a-Hexahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2(3H)-on

(1S,2R,4R,6R,7S)-1,10,10-Trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]decan-4-ol

Refernces