4-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-4-oxo-butyric acid ethyl ester

Base Information

Chemical Name:4-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-4-oxo-butyric acid ethyl ester
CAS No.:1005402-80-1
Molecular Formula:C₂₀H₂₉NO₄
Molecular Weight:347.455
Hs Code.:

Synonyms:4-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-4-oxo-butyric acid ethyl ester

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Chemical Property of 4-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-4-oxo-butyric acid ethyl ester

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Technology Process of 4-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-4-oxo-butyric acid ethyl ester

There total 4 articles about 4-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-4-oxo-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1005402-79-8
C₁₅H₁₉ClO₄

: 41720-98-3,54677-53-1,135324-85-5,174500-74-4
(R)-2-methylpyrrolidine hydrochloride

: 1005402-80-1
4-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-4-oxo-butyric acid ethyl ester

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; at 90 ℃; for 48h;

Reference yield:

: 1005402-79-8
C₁₅H₁₉ClO₄

: 765-38-8,41720-98-3,59335-84-1,79171-53-2
(R)-(-)-2-methylpyrrolidine

: 1005402-80-1
4-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-4-oxo-butyric acid ethyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃;
DOI:10.1016/j.bmcl.2011.11.037

Reference yield:

: 15118-67-9
ethyl 3-(4-methoxybenzoyl)-propionate

: 1005402-80-1
4-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-4-oxo-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane / 5 - 20 °C

2: potassium carbonate / acetone / 65 °C

3: potassium carbonate / acetonitrile / 80 °C

With boron tribromide; potassium carbonate; In dichloromethane; acetone; acetonitrile;
DOI:10.1016/j.bmcl.2011.11.037