ETHYL 3-(4-METHOXYBENZOYL)PROPIONATE

Base Information

• Chemical Name: ETHYL 3-(4-METHOXYBENZOYL)PROPIONATE
• CAS No.: 15118-67-9
• Molecular Formula: C13H16 O4
• Molecular Weight: 236.268
• Hs Code.: 2918990090
• Mol file: 15118-67-9.mol

Synonyms:Propionicacid, 3-p-anisoyl-, ethyl ester (6CI,8CI); Ethyl 3-p-anisoylpropionate

Chemical Property of ETHYL 3-(4-METHOXYBENZOYL)PROPIONATE

Chemical Property:

• Vapor Pressure: 1.62E-05mmHg at 25°C
• Melting Point: 50-54 °C(lit.)
• Refractive Index: 1.501
• Boiling Point: 365°Cat760mmHg
• Flash Point: 161.2°C
• PSA: 52.60000
• Density: 1.101g/cm³
• LogP: 2.22120

Purity/Quality:

98%Min ^*data from raw suppliers

Ethyl4-(4-methoxyphenyl)-4-oxobutyrate 97% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 3-(4-METHOXYBENZOYL)PROPIONATE

There total 25 articles about ETHYL 3-(4-METHOXYBENZOYL)PROPIONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethanol (64-17-5) + 4-(4-methoxy-phenyl)-4-oxo-butyric acid (3153-44-4) → ethyl 3-(4-methoxybenzoyl)-propionate (15118-67-9)

Guidance literature:

With toluene-4-sulfonic acid; Reflux;

DOI:10.3390/molecules23030637

Reference yield: 95.0%

1-bromo-1-(4-methoxyphenyl)ethene (29338-71-4) + ethyl 2-sulfanylacetate (623-51-8) → ethyl 3-(4-methoxybenzoyl)-propionate (15118-67-9)

Guidance literature:

With oxygen; C₄₂H₃₄F₁₀IrN₄⁽¹⁺⁾*F₆P^(1-); triethylamine; triphenylphosphine; In dichloromethane; at 20 ℃; for 7h; Irradiation;

DOI:10.1021/acs.orglett.1c02208

Reference yield: 94.0%

2-ethoxycarbonyethylzinc iodide (104089-16-9) + 4-methoxy-benzoyl chloride (100-07-2) → ethyl 3-(4-methoxybenzoyl)-propionate (15118-67-9)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl acetamide; benzene; at 60 ℃; for 0.5h; various co-solsents;

DOI:10.1016/S0040-4039(01)80887-X

upstream raw materials:

ethanol

4-(4-methoxy-phenyl)-4-oxo-butyric acid

2,2-Diethoxy-5-(4-methoxy-phenyl)-2,3-dihydro-furan

succinic acid anhydride

Downstream raw materials:

4-(p-methoxyphenyl)-4-hexenoate

4-hydroxy-4-(4-methoxy-phenyl)-hexanoic acid

Refernces

• 1、 Betori, Rick C.,May, Catherine M.,Scheidt, Karl A.. "Combined Photoredox/Enzymatic C?H Benzylic Hydroxylations". . p. 16490 - 16494. Retrieved 2019/11/03.
• 2、 -. "A process for preparing γ - ketone carbonyl compounds". Paragraph 0106; 0107; 0108. . Retrieved 2018/07/30.