(2R,4R,5R,6E,9R,10E)-9-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-11-iodo-2,4,7-trimethylundeca-6,10-dien-3-one

Base Information

Chemical Name:(2R,4R,5R,6E,9R,10E)-9-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-11-iodo-2,4,7-trimethylundeca-6,10-dien-3-one
CAS No.:1225384-91-7
Molecular Formula:C₂₉H₄₇IO₆Si
Molecular Weight:646.679
Hs Code.:

Synonyms:(2R,4R,5R,6E,9R,10E)-9-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-11-iodo-2,4,7-trimethylundeca-6,10-dien-3-one

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Chemical Property of (2R,4R,5R,6E,9R,10E)-9-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-11-iodo-2,4,7-trimethylundeca-6,10-dien-3-one

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Technology Process of (2R,4R,5R,6E,9R,10E)-9-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-11-iodo-2,4,7-trimethylundeca-6,10-dien-3-one

There total 1 articles about (2R,4R,5R,6E,9R,10E)-9-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-11-iodo-2,4,7-trimethylundeca-6,10-dien-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1225384-89-3
C₁₄H₂₅IO₂Si

: 627101-46-6
(R)-1-(3,4-Dimethoxy-benzyloxy)-2-methyl-pentan-3-one

: 1225384-91-7
(2R,4R,5R,6E,9R,10E)-9-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-11-iodo-2,4,7-trimethylundeca-6,10-dien-3-one

Guidance literature:: (R)-1-(3,4-Dimethoxy-benzyloxy)-2-methyl-pentan-3-one; With dicyclohexylboron chloride; triethylamine; In diethyl ether; at 0 ℃; for 1.5h; Inert atmosphere;

C₁₄H₂₅IO₂Si; In diethyl ether; at -78 ℃; for 3h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/ol100693c

Reference yield: 95.0%

: 1225384-91-7
(2R,4R,5R,6E,9R,10E)-9-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-11-iodo-2,4,7-trimethylundeca-6,10-dien-3-one

: 123-38-6
propionaldehyde

: 1225385-08-9
(2R,3R,4S,5R,6E,9R,10E)-9-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxybenzyloxy)-3-hydroxy-11-iodo-2,4,7-trimethylundeca-6,10-dien-5-yl propionate

Guidance literature:: propionaldehyde; With samarium diiodide; In tetrahydrofuran; at -20 ℃; Inert atmosphere;

(2R,4R,5R,6E,9R,10E)-9-(tert-butyldimethylsilyloxy)-1-(3,4-dimethoxybenzyloxy)-5-hydroxy-11-iodo-2,4,7-trimethylundeca-6,10-dien-3-one; In tetrahydrofuran; at -20 ℃; for 1h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/ol100693c