(R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-yl)-thiomethyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

Base Information

Chemical Name:(R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-yl)-thiomethyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline
CAS No.:1415656-13-1
Molecular Formula:C₂₈H₃₅N₅O₅S
Molecular Weight:553.682
Hs Code.:

Synonyms:(R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-yl)-thiomethyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-yl)-thiomethyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

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Technology Process of (R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-yl)-thiomethyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

There total 1 articles about (R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-yl)-thiomethyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: N-tert-butoxycarbonyl-1-(hydroxymethyl)-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

: 86-93-1
1-Phenyl-1H-tetrazole-5-thiol

: 1415656-13-1
(R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-yl)-thiomethyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; hexane; at 0 - 20 ℃;
DOI:10.1021/jo302157e

Reference yield: 91.0%

: 1415656-13-1
(R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-yl)-thiomethyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

: 1415656-14-2
(R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-sulfonyl)methyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

Guidance literature:: With hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide; In ethanol; water; at 0 - 20 ℃; for 12h;
DOI:10.1021/jo302157e

Reference yield:

: 1415656-13-1
(R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-yl)-thiomethyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

: 1415656-23-3
C₂₅H₃₃NO₄

Guidance literature:: Multi-step reaction with 5 steps

1: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / ethanol; water / 12 h / 0 - 20 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -35 °C

3: 5%-palladium/activated carbon; hydrogen / methanol / 24 h / 20 °C

4: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0 - 20 °C

5: sodium cyanoborohydride; zinc(II) chloride / methanol / 20 °C

With hexaammonium heptamolybdate tetrahydrate; trimethylsilyl trifluoromethanesulfonate; 5%-palladium/activated carbon; hydrogen; dihydrogen peroxide; sodium cyanoborohydride; zinc(II) chloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 2: |Julia-Kocienski Olefination;
DOI:10.1021/jo302157e