(R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-sulfonyl)methyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

Base Information

Chemical Name:(R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-sulfonyl)methyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline
CAS No.:1415656-14-2
Molecular Formula:C₂₈H₃₅N₅O₇S
Molecular Weight:585.681
Hs Code.:

Synonyms:(R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-sulfonyl)methyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

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Chemical Property of (R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-sulfonyl)methyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

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Technology Process of (R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-sulfonyl)methyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

There total 3 articles about (R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-sulfonyl)methyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1415656-13-1
(R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-yl)-thiomethyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

: 1415656-14-2
(R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-sulfonyl)methyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

Guidance literature:: With hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide; In ethanol; water; at 0 - 20 ℃; for 12h;
DOI:10.1021/jo302157e

Reference yield:

: 86-93-1
1-Phenyl-1H-tetrazole-5-thiol

: 1415656-14-2
(R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-sulfonyl)methyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; hexane / 0 - 20 °C

2: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / ethanol; water / 12 h / 0 - 20 °C

With hexaammonium heptamolybdate tetrahydrate; di-isopropyl azodicarboxylate; dihydrogen peroxide; triphenylphosphine; In tetrahydrofuran; ethanol; hexane; water; 1: |Mitsunobu Displacement;
DOI:10.1021/jo302157e

Reference yield:

: N-tert-butoxycarbonyl-1-(hydroxymethyl)-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

: 1415656-14-2
(R)-N-tert-butoxycarbonyl-1-[(1-phenyl-1H-tetrazol-5-sulfonyl)methyl]-7-methoxy-6-(pivaloyloxy)-3,4-dihydro-1H-isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; hexane / 0 - 20 °C

2: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / ethanol; water / 12 h / 0 - 20 °C

With hexaammonium heptamolybdate tetrahydrate; di-isopropyl azodicarboxylate; dihydrogen peroxide; triphenylphosphine; In tetrahydrofuran; ethanol; hexane; water; 1: |Mitsunobu Displacement;
DOI:10.1021/jo302157e