tert-butyl ((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl ((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamate
CAS No.:1403480-09-0
Molecular Formula:C₂₈H₄₁FN₂O₇S
Molecular Weight:568.707
Hs Code.:

Synonyms:tert-butyl ((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamate

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Chemical Property of tert-butyl ((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamate

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Technology Process of tert-butyl ((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamate

There total 7 articles about tert-butyl ((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1403480-08-9
tert-butyl ((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N methylphenylsulfonamido)-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamate

: 1403480-09-0
tert-butyl ((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamate

Guidance literature:: tert-butyl ((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N methylphenylsulfonamido)-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamate; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 1403480-06-7
(2S,3R)-3-(((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-N-(2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2-methylbutanamide

: 1403480-09-0
tert-butyl ((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 6.25 h / 0 - 65 °C / Inert atmosphere

1.2: 0.75 h / 0 °C

1.3: 18 h / 80 °C

2.1: triethylamine / dichloromethane / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

With dimethylsulfide borane complex; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1255212-77-1
tert-butyl ((2R,3S)-2-((tert-butyldimethylsilyl)oxy)-4-(((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)amino)-3-methyl-4-oxobutyl)(methyl)carbamate

: 1403480-09-0
tert-butyl ((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,6-dimethylpyridine; t-butyldimethylsiyl triflate / dichloromethane / 3.92 h / 0 - 20 °C

1.2: 3 h / 20 °C

1.3: 18 h / 20 °C

2.1: dimethylsulfide borane complex / tetrahydrofuran / 6.25 h / 0 - 65 °C / Inert atmosphere

2.2: 0.75 h / 0 °C

2.3: 18 h / 80 °C

3.1: triethylamine / dichloromethane / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; dimethylsulfide borane complex; t-butyldimethylsiyl triflate; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;