N-(((5R,6R)-11-(3-(3,5-dimethylisoxazol-4-yl)ureido)-8-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-methyl-9-oxo-3,5,6,7,8,9-hexahydro-2H-benzo[e][1,4,8]dioxaazacycloundecin-5-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Base Information

Chemical Name:N-(((5R,6R)-11-(3-(3,5-dimethylisoxazol-4-yl)ureido)-8-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-methyl-9-oxo-3,5,6,7,8,9-hexahydro-2H-benzo[e][1,4,8]dioxaazacycloundecin-5-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide
CAS No.:1403478-75-0
Molecular Formula:C₃₈H₄₆FN₅O₉S
Molecular Weight:767.876
Hs Code.:

N-(((5R,6R)-11-(3-(3,5-dimethylisoxazol-4-yl)ureido)-8-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-methyl-9-oxo-3,5,6,7,8,9-hexahydro-2H-benzo[e][1,4,8]dioxaazacycloundecin-5-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

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Suppliers and Price of N-(((5R,6R)-11-(3-(3,5-dimethylisoxazol-4-yl)ureido)-8-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-methyl-9-oxo-3,5,6,7,8,9-hexahydro-2H-benzo[e][1,4,8]dioxaazacycloundecin-5-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

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Chemical Property of N-(((5R,6R)-11-(3-(3,5-dimethylisoxazol-4-yl)ureido)-8-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-methyl-9-oxo-3,5,6,7,8,9-hexahydro-2H-benzo[e][1,4,8]dioxaazacycloundecin-5-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

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Technology Process of N-(((5R,6R)-11-(3-(3,5-dimethylisoxazol-4-yl)ureido)-8-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-methyl-9-oxo-3,5,6,7,8,9-hexahydro-2H-benzo[e][1,4,8]dioxaazacycloundecin-5-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

There total 15 articles about N-(((5R,6R)-11-(3-(3,5-dimethylisoxazol-4-yl)ureido)-8-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-methyl-9-oxo-3,5,6,7,8,9-hexahydro-2H-benzo[e][1,4,8]dioxaazacycloundecin-5-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403480-08-9
tert-butyl ((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N methylphenylsulfonamido)-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamate

: 1403478-75-0
N-(((5R,6R)-11-(3-(3,5-dimethylisoxazol-4-yl)ureido)-8-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-methyl-9-oxo-3,5,6,7,8,9-hexahydro-2H-benzo[e][1,4,8]dioxaazacycloundecin-5-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

2: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 16 h / -78 - 3 °C / Inert atmosphere

3: diisobutylaluminium hydride / toluene / -78 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / Molecular sieve; Inert atmosphere

5: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

6: pyridine hydrogenfluoride / tetrahydrofuran

7: N-ethyl-N,N-diisopropylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 0 - 20 °C

8: acetic acid; zinc / tetrahydrofuran / 20 h

9: dichloromethane / 4 h

With 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diisobutylaluminium hydride; pyridine hydrogenfluoride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm500994n

Reference yield:

: C₃₂H₃₈FN₃O₉S

: 1403478-75-0
N-(((5R,6R)-11-(3-(3,5-dimethylisoxazol-4-yl)ureido)-8-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-methyl-9-oxo-3,5,6,7,8,9-hexahydro-2H-benzo[e][1,4,8]dioxaazacycloundecin-5-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; zinc / tetrahydrofuran / 20 h

2: dichloromethane / 4 h

With acetic acid; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm500994n

Reference yield:

: 1403480-09-0
tert-butyl ((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamate

: 1403478-75-0
N-(((5R,6R)-11-(3-(3,5-dimethylisoxazol-4-yl)ureido)-8-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-6-methyl-9-oxo-3,5,6,7,8,9-hexahydro-2H-benzo[e][1,4,8]dioxaazacycloundecin-5-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 16 h / -78 - 3 °C / Inert atmosphere

2: diisobutylaluminium hydride / toluene / -78 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / Molecular sieve; Inert atmosphere

4: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

5: pyridine hydrogenfluoride / tetrahydrofuran

6: N-ethyl-N,N-diisopropylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 0 - 20 °C

7: acetic acid; zinc / tetrahydrofuran / 20 h

8: dichloromethane / 4 h

With 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diisobutylaluminium hydride; pyridine hydrogenfluoride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm500994n