trans-N-{4-[6-butyl-5-(4-cyclohexyloxy-phenyl)-pyridazin-3-yloxy]cyclohexyl}formamide

Base Information

Chemical Name:trans-N-{4-[6-butyl-5-(4-cyclohexyloxy-phenyl)-pyridazin-3-yloxy]cyclohexyl}formamide
CAS No.:1331775-91-7
Molecular Formula:C₂₇H₃₇N₃O₃
Molecular Weight:451.609
Hs Code.:

Synonyms:trans-N-{4-[6-butyl-5-(4-cyclohexyloxy-phenyl)-pyridazin-3-yloxy]cyclohexyl}formamide

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Chemical Property of trans-N-{4-[6-butyl-5-(4-cyclohexyloxy-phenyl)-pyridazin-3-yloxy]cyclohexyl}formamide

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Technology Process of trans-N-{4-[6-butyl-5-(4-cyclohexyloxy-phenyl)-pyridazin-3-yloxy]cyclohexyl}formamide

There total 4 articles about trans-N-{4-[6-butyl-5-(4-cyclohexyloxy-phenyl)-pyridazin-3-yloxy]cyclohexyl}formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1331775-90-6
trans-{4-[6-butyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]cyclohexyl}carbamic acid tert-butyl ester

: 1331775-91-7
trans-N-{4-[6-butyl-5-(4-cyclohexyloxy-phenyl)-pyridazin-3-yloxy]cyclohexyl}formamide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 106-32-1
octanoic acid ethyl ester

: 1331775-91-7
trans-N-{4-[6-butyl-5-(4-cyclohexyloxy-phenyl)-pyridazin-3-yloxy]cyclohexyl}formamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate; acetic acid / 12 h / 100 °C

2.1: trichlorophosphate; 2H-Pyridazin-3-one / 0.5 h / 90 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

3.2: 3 h / 50 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

With 2H-Pyridazin-3-one; lithium aluminium tetrahydride; sodium hydride; hydrazine hydrate; acetic acid; trichlorophosphate; In tetrahydrofuran; mineral oil;

Reference yield:

: 1331775-52-0
3-butyl-6-chloro-4-(4-cyclohexyloxyphenyl)pyridazine

: 1331775-91-7
trans-N-{4-[6-butyl-5-(4-cyclohexyloxy-phenyl)-pyridazin-3-yloxy]cyclohexyl}formamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

1.2: 3 h / 50 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; mineral oil;