Technology Process of benzyl cis-3-(methoxycarbonyl)pipecolate
There total 9 articles about benzyl cis-3-(methoxycarbonyl)pipecolate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 46 g / H2 / 20percent Pd/C / methanol / 16 h / 2585.7 Torr
2: 1.9 g / CuCO3*Cu(OH)2 / ethanol; H2O / 22 h / 70 °C
3: 85 percent / aq. NaOH / dioxane / 5 h
4: 88 percent / DBU / acetonitrile / 6 h / Ambient temperature
5: 1.2 g / 4N HCl / dioxane / 0.5 h
With
hydrogenchloride; sodium hydroxide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene;
palladium on activated charcoal;
In
1,4-dioxane; methanol; ethanol; water; acetonitrile;
DOI:10.1021/jm950825x
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 96 percent / H2 / 10percent Pd-C / methanol / 48 h / 2585.7 Torr
2: 100 percent / NEt3 / dioxane; H2O / 16 h / Ambient temperature
3: 100 percent / dioxane / 1) 50 deg C, 16 h, 2) 120 - 130 deg C, 0.06 mm
4: 99 percent / 70percent aq. TFA / 7 h / 0 °C
With
hydrogen; triethylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
1,4-dioxane; methanol; water;
DOI:10.1021/jo00337a018
