2-[3-bromo-1-(2-chlorophenyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-one

Base Information

Chemical Name:2-[3-bromo-1-(2-chlorophenyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-one
CAS No.:886583-61-5
Molecular Formula:C₁₈H₁₀BrCl₂N₃O₂
Molecular Weight:451.106
Hs Code.:

Synonyms:2-[3-bromo-1-(2-chlorophenyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-one

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Chemical Property of 2-[3-bromo-1-(2-chlorophenyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-one

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Technology Process of 2-[3-bromo-1-(2-chlorophenyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-one

There total 6 articles about 2-[3-bromo-1-(2-chlorophenyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871239-17-7
3-bromo-1-(2-chlorophenyl)-1H-pyrazole-5-carboxylic acid

: 20776-67-4
2-amino-5-chloro-3-methylbenzoic acid

: 886583-61-5
2-[3-bromo-1-(2-chlorophenyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-one

Guidance literature:: With 3-Methylpyridine; methanesulfonyl chloride; In acetonitrile; at -10 - 20 ℃;

Reference yield:

: 871239-14-4
(2-chlorophenyl)carbonohydrazonic dibromide

: 886583-61-5
2-[3-bromo-1-(2-chlorophenyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: potassium permanganate / acetone / 20 - 40 °C

3.1: sodium hydroxide / water; methanol / 2 h / 20 °C

3.2: pH 2

4.1: 3-Methylpyridine; methanesulfonyl chloride / acetonitrile / -10 - 20 °C

With potassium permanganate; 3-Methylpyridine; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 41052-75-9
o-chlorophenylhydrazine hydrochloride

: 886583-61-5
2-[3-bromo-1-(2-chlorophenyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / water / 0.33 h / 20 °C

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: potassium permanganate / acetone / 20 - 40 °C

5.1: sodium hydroxide / water; methanol / 2 h / 20 °C

5.2: pH 2

6.1: 3-Methylpyridine; methanesulfonyl chloride / acetonitrile / -10 - 20 °C

With hydrogenchloride; potassium permanganate; N-Bromosuccinimide; 3-Methylpyridine; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide; acetone; acetonitrile;