3-bromo-N-[4-chloro-2-[[(1-cyclopropylethyl)amino]carbonyl]-6-methylphenyl]-1-(2-chlorophenyl)-1H-pyrazole-5-carboxamide

Base Information

• Chemical Name: 3-bromo-N-[4-chloro-2-[[(1-cyclopropylethyl)amino]carbonyl]-6-methylphenyl]-1-(2-chlorophenyl)-1H-pyrazole-5-carboxamide
• CAS No.: 886583-56-8
• Molecular Formula: C₂₃H₂₁BrCl₂N₄O₂
• Molecular Weight: 536.255
• Mol file: 886583-56-8.mol

Synonyms:3-bromo-N-[4-chloro-2-[[(1-cyclopropylethyl)amino]carbonyl]-6-methylphenyl]-1-(2-chlorophenyl)-1H-pyrazole-5-carboxamide

Chemical Property of 3-bromo-N-[4-chloro-2-[[(1-cyclopropylethyl)amino]carbonyl]-6-methylphenyl]-1-(2-chlorophenyl)-1H-pyrazole-5-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-bromo-N-[4-chloro-2-[[(1-cyclopropylethyl)amino]carbonyl]-6-methylphenyl]-1-(2-chlorophenyl)-1H-pyrazole-5-carboxamide

There total 8 articles about 3-bromo-N-[4-chloro-2-[[(1-cyclopropylethyl)amino]carbonyl]-6-methylphenyl]-1-(2-chlorophenyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-cyclopropylethylamine (6240-96-6,10367-78-9,1621-24-5,195604-39-8) + 2-[3-bromo-1-(2-chlorophenyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-one (886583-61-5) → 3-bromo-N-[4-chloro-2-[[(1-cyclopropylethyl)amino]carbonyl]-6-methylphenyl]-1-(2-chlorophenyl)-1H-pyrazole-5-carboxamide (886583-56-8)

Guidance literature:

In diethyl ether; acetonitrile; at 20 ℃;

Reference yield:

Cyclopropyl methyl ketone (765-43-5) → 3-bromo-N-[4-chloro-2-[[(1-cyclopropylethyl)amino]carbonyl]-6-methylphenyl]-1-(2-chlorophenyl)-1H-pyrazole-5-carboxamide (886583-56-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol / 16 h / Reflux

2: lithium aluminium tetrahydride / diethyl ether / 8.5 h / 20 °C / Reflux

3: acetonitrile; diethyl ether / 20 °C

With lithium aluminium tetrahydride; hydroxylamine hydrochloride; sodium acetate; In diethyl ether; ethanol; acetonitrile;

Reference yield:

(2-chlorophenyl)carbonohydrazonic dibromide (871239-14-4) → 3-bromo-N-[4-chloro-2-[[(1-cyclopropylethyl)amino]carbonyl]-6-methylphenyl]-1-(2-chlorophenyl)-1H-pyrazole-5-carboxamide (886583-56-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: potassium permanganate / acetone / 20 - 40 °C

3.1: sodium hydroxide / water; methanol / 2 h / 20 °C

3.2: pH 2

4.1: 3-Methylpyridine; methanesulfonyl chloride / acetonitrile / -10 - 20 °C

5.1: acetonitrile; diethyl ether / 20 °C

With potassium permanganate; 3-Methylpyridine; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; diethyl ether; water; N,N-dimethyl-formamide; acetone; acetonitrile;

upstream raw materials:

Cyclopropyl methyl ketone

1-cyclopropylethylamine

2-[3-bromo-1-(2-chlorophenyl)-1H-pyrazol-5-yl]-6-chloro-8-methyl-4H-3,1-benzoxazin-4-one

o-chlorophenylhydrazine hydrochloride