[3-(2-amino-6-chloro-purine-9-yl)-5-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclopentyl]-methanol

Base Information

Chemical Name:[3-(2-amino-6-chloro-purine-9-yl)-5-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclopentyl]-methanol
CAS No.:1233193-60-6
Molecular Formula:C₂₈H₃₂ClN₅O₂Si
Molecular Weight:534.133
Hs Code.:

Synonyms:[3-(2-amino-6-chloro-purine-9-yl)-5-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclopentyl]-methanol

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Chemical Property of [3-(2-amino-6-chloro-purine-9-yl)-5-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclopentyl]-methanol

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Technology Process of [3-(2-amino-6-chloro-purine-9-yl)-5-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclopentyl]-methanol

There total 9 articles about [3-(2-amino-6-chloro-purine-9-yl)-5-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclopentyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1233193-59-3
9-[4-(tert-butyl-diphenyl-silanyloxy)-2-methylene-3-trityloxymethyl-cyclopentyl]-6-chloro-9H-purine-2-yl amine

: 1233193-60-6
[3-(2-amino-6-chloro-purine-9-yl)-5-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclopentyl]-methanol

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 0 - 20 ℃;

Reference yield:

: 1233193-52-6
2-((trityloxy)methyl)cyclopent-2-en-1-one

: 1233193-60-6
[3-(2-amino-6-chloro-purine-9-yl)-5-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclopentyl]-methanol

Guidance literature:: Multi-step reaction with 9 steps

1.1: borane-dimethyl sulfide complex / (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / dichloromethane / 3 h / 0 °C

2.1: 1H-imidazole / dichloromethane / 2 h / 20 °C

3.1: L-diisopinocampheylborane / tetrahydrofuran / 5 h / 0 - 20 °C

3.2: 1.75 h / 0 - 12 °C

4.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

5.1: triethylamine / dichloromethane / 1 h / 0 - 5 °C

6.1: 3-chloro-benzenecarboperoxoic acid; disodium hydrogenphosphate / dichloromethane / 2.5 h / -25 °C

6.2: -25 - 20 °C

7.1: titanium tetrachloride / tetrahydrofuran / 3.5 h / -40 - 20 °C

8.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / -20 °C

9.1: toluene-4-sulfonic acid; methanol / 4 h / 0 - 20 °C

With 1H-imidazole; methanol; disodium hydrogenphosphate; borane-dimethyl sulfide complex; titanium tetrachloride; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; L-diisopinocampheylborane; diethylazodicarboxylate; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; dichloromethane; 8.1: Mitsunobu reaction;

Reference yield:

: 1233193-55-9
3-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-2-trityloxymethyl-cyclopentanone

: 1233193-60-6
[3-(2-amino-6-chloro-purine-9-yl)-5-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclopentyl]-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: titanium tetrachloride / tetrahydrofuran / 3.5 h / -40 - 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / -20 °C

3: toluene-4-sulfonic acid; methanol / 4 h / 0 - 20 °C

With methanol; titanium tetrachloride; toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 2: Mitsunobu reaction;