(S)-2-[4-(4-trifluoromethoxyphenyl)piperazin-1-ylmethyl]-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazole

Base Information

Chemical Name:(S)-2-[4-(4-trifluoromethoxyphenyl)piperazin-1-ylmethyl]-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazole
CAS No.:681033-48-7
Molecular Formula:C₁₈H₂₀F₃N₅O₄
Molecular Weight:427.383
Hs Code.:

Synonyms:(S)-2-[4-(4-trifluoromethoxyphenyl)piperazin-1-ylmethyl]-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazole

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Chemical Property of (S)-2-[4-(4-trifluoromethoxyphenyl)piperazin-1-ylmethyl]-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazole

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Technology Process of (S)-2-[4-(4-trifluoromethoxyphenyl)piperazin-1-ylmethyl]-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazole

There total 8 articles about (S)-2-[4-(4-trifluoromethoxyphenyl)piperazin-1-ylmethyl]-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: C₁₈H₂₁BrF₃N₅O₄

: 681033-48-7
(S)-2-[4-(4-trifluoromethoxyphenyl)piperazin-1-ylmethyl]-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazole

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 18h;

Reference yield: 48.0%

: 681032-13-3
(S)-1-(2-chloro-4-nitroimidazol-1-yl)-2-methyl-3-[4-(4-trifluoromethoxyphenyl)piperazin-1-yl]propan-2-ol

: 681033-48-7
(S)-2-[4-(4-trifluoromethoxyphenyl)piperazin-1-ylmethyl]-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazole

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 ℃; for 6h; Heating / reflux;

Reference yield:

: C₁₄H₁₃BrN₄O₇

: 681033-48-7
(S)-2-[4-(4-trifluoromethoxyphenyl)piperazin-1-ylmethyl]-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazole

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / methanol / 1 h / 20 °C

2: pyridine / 16 h / 20 °C / Cooling with ice

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethyl acetate / 16 h / 20 °C

4: tert-butyl alcohol / 80 °C / Inert atmosphere

5: sodium hydride / N,N-dimethyl-formamide / 18 h / 0 - 20 °C

With pyridine; sodium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;