5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1-methyl-4-piperidinyl)-1H-pyrazole-4-carboxylic acid hydrochloride

Base Information

Chemical Name:5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1-methyl-4-piperidinyl)-1H-pyrazole-4-carboxylic acid hydrochloride
CAS No.:1195782-19-4
Molecular Formula:C₃₈H₄₅N₅O₆S*ClH
Molecular Weight:736.332
Hs Code.:

5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1-methyl-4-piperidinyl)-1H-pyrazole-4-carboxylic acid hydrochloride

Synonyms:5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1-methyl-4-piperidinyl)-1H-pyrazole-4-carboxylic acid hydrochloride

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Chemical Property of 5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1-methyl-4-piperidinyl)-1H-pyrazole-4-carboxylic acid hydrochloride

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Technology Process of 5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1-methyl-4-piperidinyl)-1H-pyrazole-4-carboxylic acid hydrochloride

There total 5 articles about 5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1-methyl-4-piperidinyl)-1H-pyrazole-4-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1195782-17-2
5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1-methyl-4-piperidinyl)-1H-pyrazole-4-carboxylic acid ethyl ester hydrochloride

: 1195782-19-4
5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1-methyl-4-piperidinyl)-1H-pyrazole-4-carboxylic acid hydrochloride

Guidance literature:: 5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1-methyl-4-piperidinyl)-1H-pyrazole-4-carboxylic acid ethyl ester hydrochloride; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 19h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; methanol; water; ethyl acetate;

Reference yield:

: 1127234-87-0
13-cyclohexyl-10-[(1,1-dimethylethoxy)carbonyl]-3-methoxy-beta-oxo-7H-indolo[2,1-a][2]benzazepine-6-propanoic acid ethyl ester

: 1195782-19-4
5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1-methyl-4-piperidinyl)-1H-pyrazole-4-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2.75 h / 110 °C / Inert atmosphere

2.1: triethylamine / 1,4-dioxane; ethanol / 0.67 h / 160 °C / Inert atmosphere

3.1: 1,2-dichloro-ethane / 2 h / 20 °C / Inert atmosphere

4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Reflux

4.2: 70 °C / Inert atmosphere

5.1: water; sodium hydroxide / tetrahydrofuran; methanol / 19 h / 20 °C / Inert atmosphere

With water; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; 1,2-dichloro-ethane;

Reference yield:

: 1127234-89-2
tert-butyl 13-cyclohexyl-6-((2E,Z)-3-(dimethylamino)-2-(ethoxycarbonyl)-2-propenoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

: 1195782-19-4
5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1-methyl-4-piperidinyl)-1H-pyrazole-4-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 1,4-dioxane; ethanol / 0.67 h / 160 °C / Inert atmosphere

2.1: 1,2-dichloro-ethane / 2 h / 20 °C / Inert atmosphere

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Reflux

3.2: 70 °C / Inert atmosphere

4.1: water; sodium hydroxide / tetrahydrofuran; methanol / 19 h / 20 °C / Inert atmosphere

With water; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; 1,2-dichloro-ethane;