13-cyclohexyl-6-[4-(3,7-dioxa-9-azabicyclo[3.3.1]non-9-ylcarbonyl)-1-(1-methyl-4-piperidinyl)-1H-pyrazol-5-yl]-3-methoxy-N-[(1-methylethyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

Base Information

Chemical Name:13-cyclohexyl-6-[4-(3,7-dioxa-9-azabicyclo[3.3.1]non-9-ylcarbonyl)-1-(1-methyl-4-piperidinyl)-1H-pyrazol-5-yl]-3-methoxy-N-[(1-methylethyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide
CAS No.:1195777-91-3
Molecular Formula:C₄₄H₅₄N₆O₇S
Molecular Weight:811.015
Hs Code.:

13-cyclohexyl-6-[4-(3,7-dioxa-9-azabicyclo[3.3.1]non-9-ylcarbonyl)-1-(1-methyl-4-piperidinyl)-1H-pyrazol-5-yl]-3-methoxy-N-[(1-methylethyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

Synonyms:13-cyclohexyl-6-[4-(3,7-dioxa-9-azabicyclo[3.3.1]non-9-ylcarbonyl)-1-(1-methyl-4-piperidinyl)-1H-pyrazol-5-yl]-3-methoxy-N-[(1-methylethyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

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Chemical Property of 13-cyclohexyl-6-[4-(3,7-dioxa-9-azabicyclo[3.3.1]non-9-ylcarbonyl)-1-(1-methyl-4-piperidinyl)-1H-pyrazol-5-yl]-3-methoxy-N-[(1-methylethyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

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Technology Process of 13-cyclohexyl-6-[4-(3,7-dioxa-9-azabicyclo[3.3.1]non-9-ylcarbonyl)-1-(1-methyl-4-piperidinyl)-1H-pyrazol-5-yl]-3-methoxy-N-[(1-methylethyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

There total 5 articles about 13-cyclohexyl-6-[4-(3,7-dioxa-9-azabicyclo[3.3.1]non-9-ylcarbonyl)-1-(1-methyl-4-piperidinyl)-1H-pyrazol-5-yl]-3-methoxy-N-[(1-methylethyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1127237-89-1
3,7-dioxa-9-azabicyclo[3.3.1]nonane hydrochloride

: 1195782-19-4
5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1-methyl-4-piperidinyl)-1H-pyrazole-4-carboxylic acid hydrochloride

: 1195777-91-3
13-cyclohexyl-6-[4-(3,7-dioxa-9-azabicyclo[3.3.1]non-9-ylcarbonyl)-1-(1-methyl-4-piperidinyl)-1H-pyrazol-5-yl]-3-methoxy-N-[(1-methylethyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

Guidance literature:: 5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1-methyl-4-piperidinyl)-1H-pyrazole-4-carboxylic acid hydrochloride; With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1.3h; Inert atmosphere;

3,7-dioxa-9-azabicyclo[3.3.1]nonane hydrochloride; With dmap; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1127234-87-0
13-cyclohexyl-10-[(1,1-dimethylethoxy)carbonyl]-3-methoxy-beta-oxo-7H-indolo[2,1-a][2]benzazepine-6-propanoic acid ethyl ester

: 1195777-91-3
13-cyclohexyl-6-[4-(3,7-dioxa-9-azabicyclo[3.3.1]non-9-ylcarbonyl)-1-(1-methyl-4-piperidinyl)-1H-pyrazol-5-yl]-3-methoxy-N-[(1-methylethyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2.75 h / 110 °C / Inert atmosphere

2.1: triethylamine / 1,4-dioxane; ethanol / 0.67 h / 160 °C / Inert atmosphere

3.1: 1,2-dichloro-ethane / 2 h / 20 °C / Inert atmosphere

4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Reflux

4.2: 70 °C / Inert atmosphere

5.1: water; sodium hydroxide / tetrahydrofuran; methanol / 19 h / 20 °C / Inert atmosphere

6.1: HATU / N,N-dimethyl-formamide / 1.3 h / 20 °C / Inert atmosphere

6.2: 16 h / 20 °C / Inert atmosphere

With water; triethylamine; HATU; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1127234-89-2
tert-butyl 13-cyclohexyl-6-((2E,Z)-3-(dimethylamino)-2-(ethoxycarbonyl)-2-propenoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylate

: 1195777-91-3
13-cyclohexyl-6-[4-(3,7-dioxa-9-azabicyclo[3.3.1]non-9-ylcarbonyl)-1-(1-methyl-4-piperidinyl)-1H-pyrazol-5-yl]-3-methoxy-N-[(1-methylethyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / 1,4-dioxane; ethanol / 0.67 h / 160 °C / Inert atmosphere

2.1: 1,2-dichloro-ethane / 2 h / 20 °C / Inert atmosphere

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Reflux

3.2: 70 °C / Inert atmosphere

4.1: water; sodium hydroxide / tetrahydrofuran; methanol / 19 h / 20 °C / Inert atmosphere

5.1: HATU / N,N-dimethyl-formamide / 1.3 h / 20 °C / Inert atmosphere

5.2: 16 h / 20 °C / Inert atmosphere

With water; triethylamine; HATU; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;