(S)-benzyl 3-((S)-2-benzyl-3-(tert-butoxy)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidine-1-carboxylate

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Chemical Name:(S)-benzyl 3-((S)-2-benzyl-3-(tert-butoxy)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidine-1-carboxylate
CAS No.:1316848-10-8
Molecular Formula:C₂₇H₃₂N₂O₄
Molecular Weight:448.562
Hs Code.:

Synonyms:(S)-benzyl 3-((S)-2-benzyl-3-(tert-butoxy)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-benzyl 3-((S)-2-benzyl-3-(tert-butoxy)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidine-1-carboxylate

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Technology Process of (S)-benzyl 3-((S)-2-benzyl-3-(tert-butoxy)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidine-1-carboxylate

There total 7 articles about (S)-benzyl 3-((S)-2-benzyl-3-(tert-butoxy)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1316847-99-0
(S)-benzyl 3-(((S)-1-(tert-butoxy)-1-oxo-3-phenylpropan-2-yl)amino)pyrrolidine-1-carboxylate hydrochloride

: 73818-55-0,15596-07-3
Bestmann ylide

: 1316848-10-8
(S)-benzyl 3-((S)-2-benzyl-3-(tert-butoxy)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidine-1-carboxylate

Guidance literature:: In tetrahydrofuran; at 75 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ja2033734

Reference yield:

: 1316847-95-6
(S)-benzyl 3-(((S)-1-(tert-butoxy)-1-oxo-3-phenylpropan-2-yl)amino)pyrrolidine-1-carboxylate

: 1316848-10-8
(S)-benzyl 3-((S)-2-benzyl-3-(tert-butoxy)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / diethyl ether / 0.17 h / 0 °C / Inert atmosphere

2: tetrahydrofuran / 3 h / 75 °C / Inert atmosphere

With hydrogenchloride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja2033734

Reference yield:

: C₁₃H₁₄F₃NO₅S

: 1316848-10-8
(S)-benzyl 3-((S)-2-benzyl-3-(tert-butoxy)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / -78 - 25 °C / Inert atmosphere

2: hydrogenchloride / diethyl ether / 0.17 h / 0 °C / Inert atmosphere

3: tetrahydrofuran / 3 h / 75 °C / Inert atmosphere

With hydrogenchloride; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja2033734