chloro-acetic acid (4-chloro-phenyl)-(diethoxy-phosphoryl)-methyl ester

Base Information

• Chemical Name: chloro-acetic acid (4-chloro-phenyl)-(diethoxy-phosphoryl)-methyl ester
• CAS No.: 263722-93-6
• Molecular Formula: C₁₃H₁₇Cl₂O₅P
• Molecular Weight: 355.155
• Mol file: 263722-93-6.mol

Synonyms:chloro-acetic acid (4-chloro-phenyl)-(diethoxy-phosphoryl)-methyl ester

Chemical Property of chloro-acetic acid (4-chloro-phenyl)-(diethoxy-phosphoryl)-methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of chloro-acetic acid (4-chloro-phenyl)-(diethoxy-phosphoryl)-methyl ester

There total 2 articles about chloro-acetic acid (4-chloro-phenyl)-(diethoxy-phosphoryl)-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorobenzaldehyde (104-88-1) → chloro-acetic acid (4-chloro-phenyl)-(diethoxy-phosphoryl)-methyl ester (263722-93-6)

Guidance literature:

Multi-step reaction with 2 steps

1: KF/Al₂O₃

2: NEt₃

With aluminum oxide; potassium fluoride; triethylamine;

DOI:10.1080/10426500600919975

Reference yield:

diethyl (4-chlorophenyl)(hydroxy)methylphosphonate (108054-54-2,20641-28-5) + chloroacetyl chloride (79-04-9) → chloro-acetic acid (4-chloro-phenyl)-(diethoxy-phosphoryl)-methyl ester (263722-93-6)

Guidance literature:

With triethylamine;

DOI:10.1080/10426500600919975

Reference yield: 77.0%

chloro-acetic acid (4-chloro-phenyl)-(diethoxy-phosphoryl)-methyl ester (263722-93-6) + tegafur (17902-23-7,65732-47-0,79107-97-4) → [5-fluoro-2,6-dioxo-3-(tetrahydro-furan-2-yl)-3,6-dihydro-2H-pyrimidin-1-yl]-acetic acid (4-chloro-phenyl)-(diethoxy-phosphoryl)-methyl ester

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; In chloroform; water; at 50 - 55 ℃; for 10h;

DOI:10.1080/10426500600919975

upstream raw materials:

diethyl (4-chlorophenyl)(hydroxy)methylphosphonate

chloroacetyl chloride

4-chlorobenzaldehyde