C₂₁H₁₈ClN₅O

Base Information

Chemical Name:C₂₁H₁₈ClN₅O
CAS No.:1429501-04-1
Molecular Formula:C₂₁H₁₈ClN₅O
Molecular Weight:391.86
Hs Code.:

C<sub>21</sub>H<sub>18</sub>ClN<sub>5</sub>O

Synonyms:C₂₁H₁₈ClN₅O

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Chemical Property of C₂₁H₁₈ClN₅O

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Technology Process of C₂₁H₁₈ClN₅O

There total 7 articles about C₂₁H₁₈ClN₅O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429498-50-9
7-(3-chlorophenyl)-4-(2-hydroxyethyl)-6-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

: 1429501-04-1
C₂₁H₁₈ClN₅O

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; acetonitrile; at 70 ℃; for 8h;

Reference yield:

: 63503-60-6
3-chlorophenylboronic acid

: 1429501-04-1
C₂₁H₁₈ClN₅O

Guidance literature:: Multi-step reaction with 5 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere

2: iodine; silver trifluoroacetate / dichloromethane / 1 h / 20 °C / Cooling with ice

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; lithium chloride / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere; Sealed tube

4: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Inert atmosphere

5: sodium azide / N,N-dimethyl-formamide; acetonitrile / 8 h / 70 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium aluminium tetrahydride; sodium azide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iodine; silver trifluoroacetate; sodium carbonate; caesium carbonate; lithium chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1429500-38-8
ethyl [7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetate

: 1429501-04-1
C₂₁H₁₈ClN₅O

Guidance literature:: Multi-step reaction with 4 steps

1: iodine; silver trifluoroacetate / dichloromethane / 1 h / 20 °C / Cooling with ice

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; lithium chloride / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere; Sealed tube

3: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Inert atmosphere

4: sodium azide / N,N-dimethyl-formamide; acetonitrile / 8 h / 70 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium aluminium tetrahydride; sodium azide; iodine; silver trifluoroacetate; sodium carbonate; lithium chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;