4-(2-aminoethyl)-7-(3-chlorophenyl)-6-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one trifluoroacetate

Base Information

Chemical Name:4-(2-aminoethyl)-7-(3-chlorophenyl)-6-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one trifluoroacetate
CAS No.:1429498-68-9
Molecular Formula:C₂HF₃O₂*C₂₁H₂₀ClN₃O
Molecular Weight:479.886
Hs Code.:

Synonyms:4-(2-aminoethyl)-7-(3-chlorophenyl)-6-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one trifluoroacetate

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Chemical Property of 4-(2-aminoethyl)-7-(3-chlorophenyl)-6-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one trifluoroacetate

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Technology Process of 4-(2-aminoethyl)-7-(3-chlorophenyl)-6-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one trifluoroacetate

There total 9 articles about 4-(2-aminoethyl)-7-(3-chlorophenyl)-6-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429501-04-1
C₂₁H₁₈ClN₅O

: 1429498-68-9
4-(2-aminoethyl)-7-(3-chlorophenyl)-6-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one trifluoroacetate

Guidance literature:: With ammonium chloride; zinc; In ethanol; at 80 ℃; for 3h;

Reference yield:

: 1429498-50-9
7-(3-chlorophenyl)-4-(2-hydroxyethyl)-6-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

: 124-63-0
methanesulfonyl chloride

: 1429498-68-9
4-(2-aminoethyl)-7-(3-chlorophenyl)-6-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one trifluoroacetate

Guidance literature:: With triethanolamine; ammonium chloride; In tetrahydrofuran; ethanol; acetonitrile;

Reference yield:

: 1429500-47-9
ethyl [7-(3-chlorophenyl)-6-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetate

: 1429498-68-9
4-(2-aminoethyl)-7-(3-chlorophenyl)-6-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: bis(triphenylphosphine)palladium(II) dichloride / water; 1,4-dioxane

2: lithium aluminium tetrahydride / tetrahydrofuran

3: triethanolamine; ammonium chloride / ethanol; tetrahydrofuran; acetonitrile

With lithium aluminium tetrahydride; bis(triphenylphosphine)palladium(II) dichloride; triethanolamine; ammonium chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; water; acetonitrile;