(S)-benzyl 2-(tert-butoxycarbonylamino)-3-(6-methoxybiphenyl-3-yl)propanoate

Base Information

Chemical Name:(S)-benzyl 2-(tert-butoxycarbonylamino)-3-(6-methoxybiphenyl-3-yl)propanoate
CAS No.:1287221-45-7
Molecular Formula:C₂₈H₃₁NO₅
Molecular Weight:461.558
Hs Code.:

Synonyms:(S)-benzyl 2-(tert-butoxycarbonylamino)-3-(6-methoxybiphenyl-3-yl)propanoate

Suppliers and Price of (S)-benzyl 2-(tert-butoxycarbonylamino)-3-(6-methoxybiphenyl-3-yl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-benzyl 2-(tert-butoxycarbonylamino)-3-(6-methoxybiphenyl-3-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-benzyl 2-(tert-butoxycarbonylamino)-3-(6-methoxybiphenyl-3-yl)propanoate

There total 3 articles about (S)-benzyl 2-(tert-butoxycarbonylamino)-3-(6-methoxybiphenyl-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 591-50-4
iodobenzene

: (S)-benzyl 2-(tert-butoxycarbonylamino)-3-(4-methoxy-3-(6-methyl-4,8-dioxo-1,3,6,2-dioxazaborocan-2-yl)phenyl)propanoate

: 1287221-45-7
(S)-benzyl 2-(tert-butoxycarbonylamino)-3-(6-methoxybiphenyl-3-yl)propanoate

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In 1,4-dioxane; water; at 70 ℃; for 48h; Inert atmosphere;
DOI:10.1039/c0ob00847h

Reference yield:

: 89694-45-1
5-bromo-2-methoxyphenylboronic acid

: 1287221-45-7
(S)-benzyl 2-(tert-butoxycarbonylamino)-3-(6-methoxybiphenyl-3-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethyl sulfoxide; toluene / 6 h / Reflux

2.1: iodine; zinc / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Exothermic reaction

2.2: 6 h / 50 °C / Inert atmosphere

3.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / 1,4-dioxane; water / 48 h / 70 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; iodine; palladium diacetate; zinc; In 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 2.2: Negishi coupling reaction / 3.1: Suzuki-Miyaura reaction;
DOI:10.1039/c0ob00847h

Reference yield:

: 1287221-38-8
2-(5-bromo-2-methoxyphenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione

: 108957-20-6
(R)-N-(tert-butoxycarbonyl)-3-iodoalanine benzyl ester

: 1287221-45-7
(S)-benzyl 2-(tert-butoxycarbonylamino)-3-(6-methoxybiphenyl-3-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: iodine; zinc / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Exothermic reaction

1.2: 6 h / 50 °C / Inert atmosphere

2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / 1,4-dioxane; water / 48 h / 70 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; iodine; palladium diacetate; zinc; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1.2: Negishi coupling reaction / 2.1: Suzuki-Miyaura reaction;
DOI:10.1039/c0ob00847h