(S)-1,4,6,7-tetrahydro-6-(hydroxymethyl)-N-methyl-N-phenyl-1-(phenylmethyl)-5H-imidazo[4,5-c]pyridine-5-carboxamide

Base Information

Chemical Name:(S)-1,4,6,7-tetrahydro-6-(hydroxymethyl)-N-methyl-N-phenyl-1-(phenylmethyl)-5H-imidazo[4,5-c]pyridine-5-carboxamide
CAS No.:114787-61-0
Molecular Formula:C₂₂H₂₄N₄O₂
Molecular Weight:376.458
Hs Code.:

Synonyms:(S)-1,4,6,7-tetrahydro-6-(hydroxymethyl)-N-methyl-N-phenyl-1-(phenylmethyl)-5H-imidazo[4,5-c]pyridine-5-carboxamide

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Chemical Property of (S)-1,4,6,7-tetrahydro-6-(hydroxymethyl)-N-methyl-N-phenyl-1-(phenylmethyl)-5H-imidazo[4,5-c]pyridine-5-carboxamide

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Technology Process of (S)-1,4,6,7-tetrahydro-6-(hydroxymethyl)-N-methyl-N-phenyl-1-(phenylmethyl)-5H-imidazo[4,5-c]pyridine-5-carboxamide

There total 5 articles about (S)-1,4,6,7-tetrahydro-6-(hydroxymethyl)-N-methyl-N-phenyl-1-(phenylmethyl)-5H-imidazo[4,5-c]pyridine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: aqueous hydrogen fluoride

: 114787-60-9
(S)-1,4,6,7-tetrahydro-6-(t-butyldimethylsilyloxymethyl)-N-methyl-N-phenyl-1-(phenylmethyl)-5 H-imidazo[4,5-c ]pyridine-5-carboxamide

: 114787-61-0
(S)-1,4,6,7-tetrahydro-6-(hydroxymethyl)-N-methyl-N-phenyl-1-(phenylmethyl)-5H-imidazo[4,5-c]pyridine-5-carboxamide

Guidance literature:: With hydrogen fluoride; In chloroform; acetonitrile;

Reference yield:

: 114787-60-9
(S)-1,4,6,7-tetrahydro-6-(t-butyldimethylsilyloxymethyl)-N-methyl-N-phenyl-1-(phenylmethyl)-5 H-imidazo[4,5-c ]pyridine-5-carboxamide

: 114787-61-0
(S)-1,4,6,7-tetrahydro-6-(hydroxymethyl)-N-methyl-N-phenyl-1-(phenylmethyl)-5H-imidazo[4,5-c]pyridine-5-carboxamide

Guidance literature:: With hydrogen fluoride; In acetonitrile; for 8h; Ambient temperature;
DOI:10.1021/jm00115a014

Reference yield:

: 114995-10-7
(S)-4,5,6,7-tetrahydro-1-(phenylmethyl)-1H-imidazo<4.5-c>pyridine-6-carboxylic acid methyl ester

: 114787-61-0
(S)-1,4,6,7-tetrahydro-6-(hydroxymethyl)-N-methyl-N-phenyl-1-(phenylmethyl)-5H-imidazo[4,5-c]pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: LAH / tetrahydrofuran / Ambient temperature

2: imidazole / tetrahydrofuran; dimethylformamide / 5 h / 40 °C

3: dicyclohexylcarbodimide (DCC), hydroxybenztriazole (HOBT*H₂O) / acetonitrile / Ambient temperature

4: 2percent HF / acetonitrile / 8 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; hydrogen fluoride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00115a014