(S)-1-Benzyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine

Base Information

Chemical Name:(S)-1-Benzyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
CAS No.:114788-09-9
Molecular Formula:C₂₀H₃₁N₃OSi
Molecular Weight:357.571
Hs Code.:

Synonyms:(S)-1-Benzyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine

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Chemical Property of (S)-1-Benzyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine

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Technology Process of (S)-1-Benzyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine

There total 2 articles about (S)-1-Benzyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114788-08-8
(S)-4,5,6,7-tetrahydro-1-(phenylmethyl)-1H-imidazo<4,5-c>pyridine-6-methanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 114788-09-9
(S)-1-Benzyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; N,N-dimethyl-formamide; at 40 ℃; for 5h;
DOI:10.1021/jm00115a014

Reference yield:

: 114995-10-7
(S)-4,5,6,7-tetrahydro-1-(phenylmethyl)-1H-imidazo<4.5-c>pyridine-6-carboxylic acid methyl ester

: 114788-09-9
(S)-1-Benzyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: LAH / tetrahydrofuran / Ambient temperature

2: imidazole / tetrahydrofuran; dimethylformamide / 5 h / 40 °C

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00115a014

Reference yield:

: 114788-09-9
(S)-1-Benzyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine

: 114787-63-2
1-((S)-1-Benzyl-6-hydroxymethyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl)-2-phenyl-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide (DCC), hydroxybenztriazole (HOBT*H₂O) / acetonitrile / Ambient temperature

2: 2percent HF / acetonitrile / 8 h / Ambient temperature

With hydrogen fluoride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In acetonitrile;
DOI:10.1021/jm00115a014