ethyl 2-(2-methyl-4-(1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)-2-phenylethylthio)phenoxy)acetate

Base Information

Chemical Name:ethyl 2-(2-methyl-4-(1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)-2-phenylethylthio)phenoxy)acetate
CAS No.:1383479-81-9
Molecular Formula:C₃₀H₂₈F₃NO₃S₂
Molecular Weight:571.684
Hs Code.:

Synonyms:ethyl 2-(2-methyl-4-(1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)-2-phenylethylthio)phenoxy)acetate

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Chemical Property of ethyl 2-(2-methyl-4-(1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)-2-phenylethylthio)phenoxy)acetate

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Technology Process of ethyl 2-(2-methyl-4-(1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)-2-phenylethylthio)phenoxy)acetate

There total 5 articles about ethyl 2-(2-methyl-4-(1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)-2-phenylethylthio)phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₂F₃NOS₂

: 105-36-2
ethyl bromoacetate

: 1383479-81-9
ethyl 2-(2-methyl-4-(1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)-2-phenylethylthio)phenoxy)acetate

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.03.055

Reference yield:

: 60577-30-2
4-iodo-2-methyl-phenol

: 1383479-81-9
ethyl 2-(2-methyl-4-(1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)-2-phenylethylthio)phenoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: 0.5 h / -78 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: potassium carbonate / acetone / 6 h / 20 °C / Inert atmosphere

With 1H-imidazole; tetrabutyl ammonium fluoride; isopropylmagnesium chloride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2012.03.055

Reference yield:

: 317318-97-1
5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

: 1383479-81-9
ethyl 2-(2-methyl-4-(1-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)-2-phenylethylthio)phenoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: 0.5 h / -78 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: potassium carbonate / acetone / 6 h / 20 °C / Inert atmosphere

With 1H-imidazole; tetrabutyl ammonium fluoride; isopropylmagnesium chloride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2012.03.055