(22E,24R)-27-nor-3α,5-cyclo-6β-methoxy-24-methyl-5α-cholest-22-en-26-ol p-toluenesulfonate

Base Information

Chemical Name:(22E,24R)-27-nor-3α,5-cyclo-6β-methoxy-24-methyl-5α-cholest-22-en-26-ol p-toluenesulfonate
CAS No.:81520-58-3
Molecular Formula:C₃₅H₅₂O₄S
Molecular Weight:568.861
Hs Code.:

Synonyms:(22E,24R)-27-nor-3α,5-cyclo-6β-methoxy-24-methyl-5α-cholest-22-en-26-ol p-toluenesulfonate

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Chemical Property of (22E,24R)-27-nor-3α,5-cyclo-6β-methoxy-24-methyl-5α-cholest-22-en-26-ol p-toluenesulfonate

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Technology Process of (22E,24R)-27-nor-3α,5-cyclo-6β-methoxy-24-methyl-5α-cholest-22-en-26-ol p-toluenesulfonate

There total 7 articles about (22E,24R)-27-nor-3α,5-cyclo-6β-methoxy-24-methyl-5α-cholest-22-en-26-ol p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25819-77-6
6β-Methoxy-3α,5-cyclo-23,24-dinor-5α-cholan-22-al

: 81520-58-3
(22E,24R)-27-nor-3α,5-cyclo-6β-methoxy-24-methyl-5α-cholest-22-en-26-ol p-toluenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

2: 339 mg / H₂, quinoline / Lindlar catalyst / hexane / 3 h / Ambient temperature

3: 262 mg / propionic acid / xylene / 2 h / 130 °C

4: 587 mg / lithium aluminum hydride / diethyl ether / 1 h / Heating

5: 650 mg / pyridine / Ambient temperature; overnight

With quinoline; lithium aluminium tetrahydride; hydrogen; propionic acid; Lindlar's catalyst; In pyridine; diethyl ether; hexane; xylene;
DOI:10.1021/jo00133a036

Reference yield:

: 81477-15-8
(22S)-26,27-dinor-3α,5-cyclo-6β-methoxy-5α-cholest-23-yn-22-ol

: 81520-58-3
(22E,24R)-27-nor-3α,5-cyclo-6β-methoxy-24-methyl-5α-cholest-22-en-26-ol p-toluenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: 339 mg / H₂, quinoline / Lindlar catalyst / hexane / 3 h / Ambient temperature

2: 262 mg / propionic acid / xylene / 2 h / 130 °C

3: 587 mg / lithium aluminum hydride / diethyl ether / 1 h / Heating

4: 650 mg / pyridine / Ambient temperature; overnight

With quinoline; lithium aluminium tetrahydride; hydrogen; propionic acid; Lindlar's catalyst; In pyridine; diethyl ether; hexane; xylene;
DOI:10.1021/jo00133a036

Reference yield:

: 81477-14-7
(22R)-26,27-dinor-3α,5-cyclo-6β-methoxy-5α-cholest-23-yn-22-ol

: 81520-58-3
(22E,24R)-27-nor-3α,5-cyclo-6β-methoxy-24-methyl-5α-cholest-22-en-26-ol p-toluenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: 299 mg / lithium aluminum hydride / tetrahydrofuran / 16 h / Heating

2: 680 mg / propionic acid / xylene / 2 h / 130 °C

3: 587 mg / lithium aluminum hydride / diethyl ether / 1 h / Heating

4: 650 mg / pyridine / Ambient temperature; overnight

With lithium aluminium tetrahydride; propionic acid; In tetrahydrofuran; pyridine; diethyl ether; xylene;
DOI:10.1021/jo00133a036