4-Bromooxanilic acid hydrazide

Base Information

• Chemical Name: 4-Bromooxanilic acid hydrazide
• CAS No.: 60199-81-7
• Molecular Formula: C₈H₈BrN₃O₂
• Molecular Weight: 258.074
• Mol file: 60199-81-7.mol

Synonyms:4-Bromooxanilic acid hydrazide

Chemical Property of 4-Bromooxanilic acid hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Bromooxanilic acid hydrazide

There total 4 articles about 4-Bromooxanilic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl N-p-bromophenyloxamate (24451-15-8) → 4-Bromooxanilic acid hydrazide (60199-81-7)

Guidance literature:

With hydrazine hydrate; In ethanol; at 90 ℃; for 3h;

Reference yield:

4-bromo-aniline (106-40-1) → 4-Bromooxanilic acid hydrazide (60199-81-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.67 h

1.2: 3 h

2.1: hydrazine hydrate / ethanol / 3 h / 90 °C

With hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol;

Reference yield:

4-bromooxanilic acid (79354-51-1) → 4-Bromooxanilic acid hydrazide (60199-81-7)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 3 h / Reflux

2: hydrazine hydrate / ethanol / 3 h / Reflux

With toluene-4-sulfonic acid; hydrazine hydrate; In ethanol;

DOI:10.1021/jm3013213

upstream raw materials:

ethyl N-p-bromophenyloxamate

4-bromooxanilic acid

4-bromo-aniline

Downstream raw materials:

5-mercapto-4-phenyl-4H[1,2,4]triazole-3-carboxylic acid (4-bromo-phenyl)amide

C₂₀H₁₉BrN₄OS

3-[(4-Bromo-phenylaminooxalyl)-hydrazono]-2-oxo-2,3-dihydro-1H-indole-7-carboxylic acid

Refernces

• 1、 -. "NOVEL HETEROARYL COMPOUND, ENANTIOMER, DIASTEREOMER OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND ANTIVIRAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT". Paragraph 0823; 0826; 0827. . Retrieved 2020/02/14.
• 2、 -. "Hydrazido functionalized 2-(2-hydroxyphenyl)-2H-benzotriazoles". . . Retrieved 2008/06/13.