4-(trifluoromethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-benzenemethanamine

Base Information

• Chemical Name: 4-(trifluoromethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-benzenemethanamine
• CAS No.: 145126-91-6
• Molecular Formula: C₁₆H₁₃F₆N
• Molecular Weight: 333.276
• Mol file: 145126-91-6.mol

Synonyms:4-(trifluoromethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-benzenemethanamine

Chemical Property of 4-(trifluoromethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-benzenemethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-(trifluoromethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-benzenemethanamine

There total 7 articles about 4-(trifluoromethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-benzenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

p-Trifluoromethylbenzylamine (3300-51-4) → 4-(trifluoromethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-benzenemethanamine (145126-91-6)

Guidance literature:

With {[(PCy₃)(CO)RuH]₄(μ-O)(μ-OH)₂}; 4-tert-Butylcatechol; In chlorobenzene; at 130 ℃; for 16h; chemoselective reaction; Glovebox; Schlenk technique; Sealed tube;

DOI:10.1021/acs.joc.8b00649

Reference yield: 80.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + p-Trifluoromethylbenzylamine (3300-51-4) → 4-(trifluoromethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-benzenemethanamine (145126-91-6)

Guidance literature:

4-Trifluoromethylbenzaldehyde; p-Trifluoromethylbenzylamine; In methanol; for 4h;

With 5% Pd/C; hydrogen; In methanol;

DOI:10.1021/ja306934b

Reference yield: 80.0%

→ 4-(trifluoromethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-benzenemethanamine (145126-91-6)

Guidance literature:

With borane-ammonia complex; C₁₆H₂₉Cl₂CoN₂P; at 25 ℃; for 13h; Inert atmosphere; Schlenk technique;

upstream raw materials:

p-trifluoromethyl-N-[p-(trifluoromethyl)benzylidene]benzylamine

4-Trifluoromethylbenzaldehyde

p-Trifluoromethylbenzylamine

p-trifluoromethylbenzamide

Downstream raw materials:

1-butyl-2-(ethoxycarbonyl)-N,N-bisaziridine-2-carboxamide

p-trifluoromethyl-N-[p-(trifluoromethyl)benzylidene]benzylamine